碳酸钙联合维生素E对重度子痫前期对患者血压控制及炎症状态的辅助疗效  

Effects of adjuvant treatment with calcium carbonate and vitamin E on blood pressure control and inflammatory status in patients with severe preeclampsia

作　　者：王琴琴 郭华娟 Wang Qin-qin;Guo Hua-juan(Perinatal Health Care,Kaifeng Maternal and Child Health Hospital,Kaifeng 475002,Henan,China;Kaifeng Key Laboratory of Reproduction and Endocrinology,Kaifeng Maternal and Child Health Hospital,Kaifeng 475002,Henan,China)

机构地区：[1]开封市妇幼保健院围产保健科,河南开封475002 [2]开封市妇幼保健院,开封市生殖内分泌重点实验室,河南开封475002

出　　处：《四川生理科学杂志》2021年第10期1664-1666,共3页Sichuan Journal of Physiological Sciences

基　　金：开封市科技攻关项目(编号:2003113)。

摘　　要：目的:分析碳酸钙联合维生素E对重度子痫前期(Severe preeclampsia,SPE)对患者血压控制及炎症状态的辅助疗效。方法:选取2019年9月至2020年12月本院诊治的91例SPE患者进行研究,采用简单随机分组法分为对照组(n=45)和观察组(n=46),对照组患者采用硫酸镁20 mL静脉滴注,观察组在此基础上加用碳酸钙(600 mg Qd)联合维生素E(50 mg Tid)治疗。治疗7 d后比较两组患者的血压控制情况,同时采用酶联免疫吸附法和免疫比浊法测定血清炎症因子,如白介素6(Interleukin-6,IL-6)、超敏C反应蛋白(Hypersensitive C-reactive protein,hs-CRP)、肿瘤坏死因子α(Tumor necrosisfactor-α,TNF-α)水平;并记录妊娠结局。结果:治疗后,两组患者舒张压和收缩压均较治疗前明显降低(P<0.05),且观察组的舒张压和收缩压均低于对照组(P<0.05);治疗后,患者血清IL-6、TNF-α、hs-CRP水平均较治疗前明显降低(P<0.05),且观察组的IL-6、TNF-α、hs-CRP水平均低于对照组(P<0.05);观察组的不良妊娠结局发生率低于对照组(P<0.05)。结论:碳酸钙联合维生素E治疗SPE可显著提高患者血压控制效果,有效减轻炎症状态,降低不良妊娠结局发生率。Objective:To analyze the effects of adjuvant treatment with calcium carbonate and vitamin E on blood pressure control and inflammatory status in patients with severe preeclampsia(SPE).Methods:A total of 91 patients with SPE treated in the hospital were enrolled between September 2019 and December 2020.According to simple random grouping method,they were divided into control group(45 cases)and observation group(46 cases).The patients in control group were treated with magnesium sulfate 20 mL intravenous drip,while those in observation group were given calcium carbonate(600 mg Qd)combined with vitamin E(50 mg Tid)on basis of control group.After 7 d of treatment,blood pressure control was compared between the two groups.The levels of serum inflammatory factors,including interleukin 6(IL-6),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factorα(TNF-α)were detected by enzyme-linked immunosorbent assay and immunoturbidimetry.And pregnancy outcomes were recorded.Results:After treatment,diastolic blood pressure and systolic blood pressure in both groups were significantly decreased(P<0.05),which were lower in observation group than control group(P<0.05).After treatment,levels of serum IL-6,TNF-αand hs-CRP in both groups were significantly decreased(P<0.05),which were lower in observation group than control group(P<0.05).The incidence of adverse pregnancy outcomes in observation group was lower than that in control group(P<0.05).Conclusion:The calcium carbonate combined with vitamin E can significantly improve blood pressure control effect,relieve inflammation status and reduce the incidence of adverse pregnancy outcomes in SPE patients.

关 键 词：碳酸钙 维生素E 重度子痫前期 

分 类 号：R71[医药卫生—妇产科学]