聚甘露糖醛酸胶束的制备及其载药性能  

Preparation of Poly Mannuronic Acid Micelle and Drug-loading Ability

作　　者：孙家曦 王腾斌 陈祥艳 张永勤[2] SUN Jiaxi;WANG Tengbin;CHEN Xiangyan;ZHANG Yongqin(Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,China)

机构地区：[1]中国海洋大学海洋药物教育部重点实验室,山东省糖科学与糖工程重点实验室,山东青岛266003 [2]青岛科技大学化工学院,山东青岛266042

出　　处：《青岛科技大学学报（自然科学版）》2022年第1期21-27,共7页Journal of Qingdao University of Science and Technology:Natural Science Edition

基　　金：山东省重点研发计划项目(2019GSF107081);青岛市科技民生计划项目(17-6-3-28-gx).

摘　　要：以脱氧胆酸为原料通过碳二亚胺法成功制备了聚甘露糖醛酸两亲性聚合物胶束(PM-cc-DA),并通过评估PM-cc-DA胶束的理化性质和载药性能来确定PM-cc-DA最佳制备方法。结果表明所制备PM-cc-DA胶束为均匀球状胶束,粒径为186nm,PDI为0.186,具有良好粒径分布,其临界胶束浓度为67.3mg·L^(-1),这表明胶束具有一定的稳定性。所制备载药胶束其载药量及包封率为13.7%及69.2%,载药性能较好,并且PBS溶液中36h内释药量为25.4%,对药物的保护能力较好,有望成为递送抗肿瘤药物的理想的胶束材料。The polymannuronic acid amphiphilic polymer micelles(PM-cc-DA)were successfully prepared by the carbodiimide method using deoxycholic acid as raw materials,and the physicochemical properties and loading of PM-cc-DA micelles were evaluated.The PM-cc-DA bland micelles were prepared which were uniform spherical shapes with particle size of 186 nm and PDI of 0.186.The critical micelle concentration was 67.3mg·L^(-1) which means good stability in dispersed medium.PM-cc-DA/DOX prepared successfully and its drug loading and encapsulation efficiency was 13.7%and 69.2%,25.4%DOX was released for PMcc-DA/DOX micelle in PBS medium.Polymannuronic acid has the potential to be an ideal micellar material for the antitumor drug delivery system.

关 键 词：聚甘露糖醛酸 胶束 乙二胺 脱氧胆酸 

分 类 号：R943[医药卫生—药剂学]