Neuron-fibrous scaffold interfaces in the peripheral nervous system: a perspective on the structural requirements  

作　　者：Sanaz Behtaj James A.St John Jenny A.K.Ekberg Maksym Rybachuk 

机构地区：[1]Clem Jones Centre for Neurobiology and Stem Cell Research,Griffith University,Queensland,Australia [2]Menzies Health Institute Queensland,Griffith University,Southport,Australia [3]Griffith Institute for Drug Discovery,Nathan,Australia [4]School of Engineering and Built Environment,Griffith University,Nathan,Australia [5]Centre for Quantum Dynamics and Australian Attosecond Science Facility,Griffith University,Nathan,Australia

出　　处：《Neural Regeneration Research》2022年第9期1893-1897,共5页中国神经再生研究（英文版）

基　　金：supported by a Garnett-Passe and Rodney Williams Memorial Foundation grant(to JE);a National Health and Medical Research Council grant,No.APP1183799(to JASJ and JAKE).

摘　　要：The nerves of the peripheral nervous system are not able to effectively regenerate in cases of severe neural injury.This can result in debilitating consequences,including morbidity and lifelong impairments affecting the quality of the patient’s life.Recent findings in neural tissue engineering have opened promising avenues to apply fibrous tissue-engineered scaffolds to promote tissue regeneration and functional recovery.These scaffolds,known as neural scaffolds,are able to improve neural regeneration by playing two major roles,namely,by being a carrier for transplanted peripheral nervous system cells or biological cues and by providing structural support to direct growing nerve fibers towards the target area.However,successful implementation of scaffold-based therapeutic approaches calls for an appropriate design of the neural scaffold structure that is capable of up-and down-regulation of neuron-scaffold interactions in the extracellular matrix environment.This review discusses the main challenges that need to be addressed to develop and apply fibrous tissue-engineered scaffolds in clinical practice.It describes some promising solutions that,so far,have shown to promote neural cell adhesion and growth and a potential to repair peripheral nervous system injuries.

关 键 词：electrospun scaffold extracellular matrix nerve conduit neural tissue engineering physical lumen filler scaffold topography structural support surface interaction 

分 类 号：R318.08[医药卫生—生物医学工程] R745[医药卫生—基础医学]