清瘟解毒汤联合常规治疗对热毒壅滞型细菌性脓毒血症患者的临床疗效  

Clinical effects of Qingwen Jiedu Decoction combined with conventional treatment on patients with bacterial sepsis due to Heat⁃Toxin Stagnation

作　　者：林瑶瑶 林先萍 霍娟勇[1] LIN Yao-yao;LIN Xian-ping;HUO Juan-yong(Hainan Provincial Hospital of Traditional Chinese Medicine,Haikou 570000,China;The First Hospital Affiliated to Hainan Medical College,Haikou 570102,China)

机构地区：[1]海南省中医院,海南海口570000 [2]海南医学院第一附属医院,海南海口570102

出　　处：《中成药》2022年第1期87-91,共5页Chinese Traditional Patent Medicine

基　　金：海南自然科学基金面上项目(817343)。

摘　　要：目的考察清瘟解毒汤联合常规治疗对热毒壅滞型细菌性脓毒血症患者的临床疗效。方法94例患者随机分为对照组和观察组,每组47例,对照组给予常规治疗(抗感染、吸氧、早期体液复苏等),观察组在对照组基础上加用清瘟解毒汤,疗程2周。检测临床疗效、CKMB、Scr、ALT、TGF⁃β1、CHE、SOFA评分、WBC、PCT、CRP、NK细胞、PT、CD4+/CD8+、并发症发生率变化。结果观察组总有效率高于对照组(P<0.05),并发症发生率更低(P<0.05)。治疗后,2组CKMB、Scr、ALT、TGF⁃β1、SOFA评分、WBC、PCT、TNF⁃α降低(P<0.05),PT缩短(P<0.05),CHE、NK细胞、CD4+/CD8+升高(P<0.05),以观察组更明显(P<0.05)。结论清瘟解毒汤联合常规治疗可促进热毒壅滞型细菌性脓毒血症患者感染康复,减轻炎症反应,提高免疫力,保护脏器功能,降低并发症发生率。AIM To investigate the clinical effects of Qingwen Jiedu Decoction combined with conventional treatment on patients with bacterial sepsis due to Heat⁃Toxin Stagnation.METHODS Ninety⁃four patients were randomly assigned into control group(47 cases)for 2⁃week intervention of conventional treatment(anti⁃infection,oxygen uptake,early fluid resuscitation,etc.),and observation group(47 cases)for 2⁃week intervention of both Qingwen Jiedu Decoction and conventional treatment.The changes in clinical efficacy,CKMB,Scr,ALT,TGF⁃β1,CHE,SOFA score,WBC,PCT,CRP,NK cells,PT,CD4+/CD8+and incidence of complications were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05),along with lower incidence of complications(P<0.05).After the treatment,the two groups displayed decreased CKMB,Scr,ALT,TGF⁃β1,SOFA score,WBC,PCT and TNF⁃α(P<0.05),shortened PT(P<0.05),and increased CHE,NK cells and CD4+/CD8+(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with bacterial sepsis due to Heat⁃Toxin Stagnation,Qingwen Jiedu Decoction combined with conventional treatment can promote infection recovery,alleviate inflammation reactions,enhance immunity,protect organ functions,and reduce incidence of complications.

关 键 词：清瘟解毒汤 常规治疗 细菌性脓毒血症 热毒壅滞 

分 类 号：R287[医药卫生—中药学]