白庀合剂联合西药治疗血热风燥型银屑病的疗效观察  

Clinical Observation on the Efficacy of Baiyu Mixture Combined with Western Medicine in Treating Psoriasis of Blood Heat and Wind Dryness

作　　者：陈芳[1] 郭顺[1] 施建新[1] CHEN Fang;GUO Shun;SHI Jian-xin(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing Jiangsu 210029)

机构地区：[1]南京中医药大学附属医院皮肤科,江苏南京210029

出　　处：《世界中西医结合杂志》2021年第11期2051-2055,2060,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金项目(81603626)。

摘　　要：目的探讨白庀合剂联合西药治疗血热风燥型银屑病的疗效观察。方法选取2017年1月—2020年12月期间南京中医药大学附属医院皮肤科收治的120例血热风燥型银屑病患者作为研究对象,采用随机数字表法将其分为对照组和治疗组,每组各60例。对照组采用常规西医治疗,治疗组采用白庀合剂联合常规西药治疗,两组患者均治疗12周。治疗完成后,观察两组患者临床疗效,比较两组患者治疗前后中医证候积分、炎症指标及不良反应情况。结果治疗后对照组患者总有效率为77.59%(45/58),治疗组患者总有效率为94.74%(54/57),两组比较,差异有统计学意义(P<0.05)。治疗后两组患者中医症状评分均较治疗前明显降低,差异有统计学意义(P<0.05);且治疗组中医症状评分较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者血清肿瘤坏死因子-α(Tumor necrosis factor alpha,TNF-α)、白介素-1(Interleukin-1,IL-1)、白介素-6(Interleukin-6,IL-6)水平均较治疗前明显降低,差异有统计学意义(P<0.05);且治疗组TNF-α,IL-1、IL-6水平较对照组明显降低,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率分别为27.59%和26.32%,两组比较,差异无统计学意义(P>0.05)。结论白庀合剂联合西药能够有效地改善血热风燥型银屑病的症状且不增加治疗的毒副作用。Objective To explore the clinical observation of the curative effect of Baiyu Mixture combined with western medicine in the treatment of psoriasis of blood heat and wind dryness.Methods From January 2017 to December 2020,120 patients with blood-heat and wind-drying psoriasis were selected as the research objects,and they were divided into a control group and a treatment group by a random number table method.Each group was divided into a control group and a treatment group.60 cases each group.The control group was treated with conventional western medicine,and the treatment group was treated with Baiyu Mixture combined with conventional western medicine.Patients in both groups were treated for 12 weeks.After the treatment was completed,the clinical efficacy of the two groups of patients,and compare the scores of TCM syndromes,inflammation indicators and adverse reactions between the two groups before and after treatment were compared.Results After treatment,the total effective rate of patients in the control group was 77.59%(45/58),and the total effective rate of patients in the treatment group was 94.74%(54/57).The difference between the two groups was statistically significant(P<0.05).After treatment,the TCM symptom scores of the two groups of patients were significantly lower than those before treatment,and the difference was statistically significant(P<0.05);and the TCM symptom scores of the treatment group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of TNF-α,IL-1 and IL-6 in the two groups were significantly lower than before treatment,and the difference was statistically significant(P<0.05);and the levels of TNF-α,IL-1 and IL-6 in the treatment group It was significantly lower than the control group,and the difference was statistically significant(P<0.05).During the treatment period,the incidence of adverse reactions in the two groups were 27.59%and 26.32%,respectively.There was no statistically significant dif

关 键 词：银屑病 血热风燥型 白庀合剂 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]