补肾通淋汤联合左氧氟沙星治疗慢性肾盂肾炎的临床疗效及其对血尿β_(2)-微球蛋白、肾功能和免疫球蛋白水平的影响  

Effect of Bushen Tonglin Decoction Combined with Levofloxacin on Chronic Pyelonephritis and Its Effects on Hematuriaβ_(2)-MG,Renal Function and Immunoglobulin

作　　者：宋妮 游越[1] SONG Ni;YOU Yue(Traditional Chinese Medicine Hospital of Qinhuangdao,Qinhuangdao Hebei 066000)

机构地区：[1]河北省秦皇岛市中医医院,河北秦皇岛066000

出　　处：《世界中西医结合杂志》2021年第11期2056-2060,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：2018年度河北省医学科学研究重点课题计划项目(20180761)。

摘　　要：目的探讨补肾通淋汤配合左氧氟沙星治疗慢性肾盂肾炎的临床疗效及其对血尿β2-微球蛋白(β2-MG)、肾功能和免疫球蛋白水平的影响。方法选取2018年1月—2019年4月期间在河北省秦皇岛市中医医院治疗的80例慢性肾盂肾炎患者,随机分为对照组39例,治疗组41例。对照组采用左氧氟沙星治疗,治疗组在此基础上联合使用补肾通淋汤,比较两组患者的临床治疗效果、临床症状变化情况及肌酐清除率(CCr)、血、尿β2-MG、肾功能、免疫球蛋白水平,不良反应发生率。结果治疗后治疗组总有效率87.80%(36/41)明显高于对照组总有效率74.36%(29/39),两组比较,差异有统计学意义(P<0.05)。治疗后治疗组排尿不适、腰酸腰痛、夜尿增多临床症状方面好转率均明显高于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者CCr水平均较治疗前明显升高,差异有统计学意义(P<0.05),且治疗组治疗后CCr水平明显高于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者血、尿β2-MG水平均较治疗前明显降低,差异有统计学意义(P<0.05),且治疗组治疗后血、尿β2-MG水平明显低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者Scr、BUN水平均较治疗前明显降低,差异有统计学意义(P<0.05);且治疗组治疗后Scr、BUN水平均明显低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者IgG、IgA和IgM水平均较治疗前明显升高,差异有统计学意义(P<0.05);且治疗组治疗后IgG、IgA和IgM水平均明显高于对照组,两组比较,差异有统计学意义(P<0.05)。治疗期间,治疗组呕吐4.88%(2/41)、腹痛2.44%(1/41)、头晕4.88%(2/41)、头痛2.44%(1/41);对照组呕吐23.08%(9/39)、腹痛23.08%(9/39)、头晕20.51%(8/39)、头痛20.51%(8/39),两组比较,差异有统计学意义(P<0.05)。结论慢性肾盂肾炎患者采用补肾通淋汤联合左氧氟沙星治疗,可Objective To investigate the clinical efficacy of Bushen Tonglin Decoction combined with levofloxacin in the treatment of chronic pyelonephritis and its effect on hematuriaβ2-MG,renal function and immunoglobulin levels.Methods total of 80 patients with chronic pyelonephritis who were treated in the Hospital of Traditional Chinese Medicine in Qinhuangdao City,Hebei Province from January 2018 to April 2019 were randomly divided into a control group of 39 cases and a treatment group of 41 cases.The control group was treated with levofloxacin,and the treatment group was combined with Bushen Tonglin Decoction on this basis.The clinical treatment effects,changes in clinical symptoms and creatinine clearance(CCr),blood and urineβ2-microglobulin(β2)were compared between the two groups.The renal function,immunoglobulin level,and incidence of adverse reactions were also compared.Results After treatment,the total effective rate of the treatment group was 87.80%(36/41)was significantly higher than that of the control group was 74.36%(29/39).The difference between the two groups was statistically significant(P<0.05).After treatment,the improvement rate of clinical symptoms of urinary discomfort,backache,backache,and nocturia in the treatment group was significantly higher than that in the control group.The difference between the two groups was statistically significant(P<0.05).After treatment,the CCr level of the two groups of patients was significantly higher than that before treatment,the difference was statistically significant(P<0.05),and the CCr level of the treatment group after treatment was significantly higher than that of the control group,and the difference between the two groups was statistically significant(P<0.05).After treatment,the blood and urineβ2-MG levels of the two groups were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).After treatment,the blood and urineβ2-MG levels of the treatment group were significantly lower than those of the control

关 键 词：补肾通淋汤 慢性肾盂肾炎 左氧氟沙星 

分 类 号：R277.5[医药卫生—中医学]