清肺解毒方对社区获得性肺炎痰热壅肺证患者肺功能、炎性因子及免疫功能的影响  

Effect of QingfeiJiedu Prescription on Pulmonary Function,Inflammatory Factor and Immune Function Patients with Community-Acquired Pneumonia with Phlegm-Heat Syndrome

作　　者：尹贤哲 韩天雄[1] YIN Xian-zhe;HAN Tian-xiong(Department of Traditional Chinese Medicine,Shanghai 10th People's Hospital,Shanghai 200072)

机构地区：[1]上海市第十人民医院中医科,上海200072

出　　处：《世界中西医结合杂志》2021年第11期2115-2118,2123,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：上海市进一步加快中医药事业发展三年行动计划(2018年-2020年)项目[ZY(2018-2020)-CCCX-1003]。

摘　　要：目的探讨清肺解毒方对社区获得性肺炎(Community-acquired pneumonia,CAP)痰热壅肺证患者肺功能、炎性因子及免疫功能的影响。方法选取2018年6月-2019年12月期间上海市第十人民医院中医科收治的110例CAP痰热壅肺证患者作为研究对象,按随机数字表法分为对照组55例和研究组55例。对照组给予常规西医治疗,在此基础上研究组给予清肺解毒方治疗。治疗后观察两组患者临床疗效、临床症状消失时间,并对治疗前后中医证候积分、肺功能指标、炎性因子及免疫功能指标进行分析比较。结果治疗后研究组总有效率94.55%(52/55),对照组总有效率72.73%(40/55),两组比较,差异有统计学意义(P<0.05)。治疗后研究组体温恢复时间、咯痰消失时间、咳嗽消失时间及肺部啰音消失时间均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者肺功能FVC、FEV1、MMF、PEmax及PImax指标均较治疗前明显升高,差异有统计学意义(P<0.05);且研究组治疗后肺功能FVC、FEV1、MMF、PEmax及PImax指标均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者IL-6、TNF-α、CD8^(+)均较治疗前降低,CD4^(+)、CD4^(+)/CD8^(+)均较治疗前明显升高,差异有统计学意义(P<0.05);且研究组IL-6、TNF-α、CD8^(+)均较对照组明显降低,CD4^(+)、CD4^(+)/CD8^(+)均较对照组明显升高,差异有统计学意义(P<0.05)。结论清肺解毒方治疗CAP痰热壅肺证的效果显著,能明显改善患者临床症状和肺功能,减轻炎症反应,提高免疫功能,从而促进病情恢复。Objective To investigate the effect of QingfeiJiedu recipe on pulmonary function,inflammatory factors and immune function in patients with community acquired pneumonia(CAP)phlegm-heat syndrome.Methods From June 2018 to December 2019,110 patients with CAP phlegm-heat obstructing lung syndrome admitted to the Department of Traditional Chinese Medicine,Shanghai Tenth People's Hospital were selected as the research objects,and they were divided into the control group and the study group according to the random number table method.55 cases.The control group was given conventional western medicine treatment,and on this basis,the study group was given QingfeiJiedu Decoction.The clinical curative effect,time of clinical symptom disappearance,TCM syndrome score,pulmonary function index,inflammatory factor and immune function index before and after treatment were analyzed and compared between two groups.Results After treatment,the total effective rate of the study group was 94.55%(52/55),and the total effective rate of the control group was 72.73%(40/55).The difference between the two groups was statistically significant(P<0.05).After treatment,the study group's body temperature recovery time,sputum disappearance time,cough disappearance time and lung rales disappearance time were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the pulmonary function FVC,FEV1,MMF,PEmax and PImax indexes of the two groups of patients were significantly higher than before treatment,and the difference was statistically significant(P<0.05);and the lung function FVC,FEV1,MMF,PEmax of the study group after treatment and PImax indicators were significantly higher than the control group,the difference was statistically significant(P<0.05).IL-6 and TNF in the two groups after treatment-α、CD4^(+)and CD4^(+)/CD8^(+)were significantly higher than those before treatment(P<0.05);IL-6 and TNF in the study group-α、CD8^(+)was significantly lower than that in the control grou

关 键 词：清肺解毒方 社区获得性肺炎 痰热壅肺证 肺功能 炎性因子 免疫功能 

分 类 号：R563.1[医药卫生—呼吸系统]