磁压榨技术用于食管吻合重建的实验研究  

Experimental study of magnetic compression technique for anastomosis reconstruction of esophagus

作　　者：张苗苗[1,2] 吉琳 刘培楠 张涵芷 牟星宜 徐庶钦 张勇 吕毅[1,2] 严小鹏[1,2] ZHANG Miaomiao;JI Lin;LIU Peinan;ZHANG Hanzhi;MOU Xingyi;XU Shuqin;ZHANG Yong;LV Yi;YAN Xiaopeng(Department of Hepatobiliary Surgery,The First Affiliated Hospital of Xi’an Jiaotong University,Xi'an,710061,P.R.China;National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine,The First Affiliated Hospital of Xi’an Jiaotong University,Xi'an,710061,P.R.China;Qide College,Xi’an Jiaotong University,Xi'an,710061,P.R.China;Zonglian College,Xi’an Jiaotong University,Xi'an,710061,P.R.China;Department of Thoracic Surgery,The First Affiliated Hospital of Xi’an Jiaotong University,Xi'an,710061,P.R.China)

机构地区：[1]西安交通大学第一附属医院肝胆外科,西安710061 [2]西安交通大学第一附属医院精准外科与再生医学国家地方联合工程研究中心,西安710061 [3]西安交通大学启德书院,西安710061 [4]西安交通大学宗濂书院,西安710061 [5]西安交通大学第一附属医院胸外科,西安710061

出　　处：《中国胸心血管外科临床杂志》2022年第1期95-99,共5页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金(81700545);陕西省创新能力支撑计划(2020KJXX-022);中央高校基本科研业务费专项资金(xjj2018jchz14);西安交通大学大学生创新训练项目(S202110698376)。

摘　　要：目的探讨基于磁压榨技术设计的磁吻合环在食管吻合重建中的可行性。方法根据SD大鼠食管解剖特点自行设计食管磁吻合环。以SD大鼠为动物模型(n=10,雌雄各半),利用磁吻合环完成颈段食管的磁吻合重建,记录手术操作时间、动物生存情况、术后并发症、磁环排出时间等。术后2周处死动物,获取食管吻合口标本,测量吻合口爆破压、肉眼观察吻合口形成情况。结果对10只SD大鼠均成功实施了食管磁吻合重建,中位吻合时间11(8~13)min,术后所有大鼠均存活良好,未见吻合口瘘、吻合口狭窄、磁环崁顿等。磁环中位排出时间为8(5~10)d。吻合口爆破压300 mm Hg以上。肉眼观察吻合口肌层愈合良好,黏膜层光滑平整。结论磁压榨技术可用于食管吻合重建,具有操作简单、吻合效果可靠等优点,具有临床应用前景。Objective To investigate the feasibility of magnamosis rings designed based on magnetic compression technique in esophageal anastomosis reconstruction.Methods According to the anatomical characteristics of esophagus in SD rats,the esophageal magnamosis rings were designed.SD rats were used as animal models(n=10,5 males and 5 females)to complete the magnetic anastomosis reconstruction of the cervical esophagus using magnamosis rings,and the operation time,animal survival,postoperative complications,magnetic rings excretion time were recorded.Two weeks after operation,the rats were killed,and the esophageal anastomotic specimens were obtained.The blasting pressure of the anastomotic site was measured and the formation of the anastomotic site was observed with naked eyes.Results Esophageal magnamosis was successfully performed in 10 SD rats,and the median operation time was 11(8-13)min.All rats survived without anastomotic leakage,anastomotic stenosis,or magnetic rings incarceration.The magnetic rings were discharged after 8(5-10)days and the burst pressure was higher than 300 mm Hg.Visual observation showed that the anastomotic muscle healed well and the mucosa was smooth.Conclusion The magnetic compression technique can be used for anastomosis reconstruction of esophagus,which has the advantages of simple operation and reliable anastomosis effect,and has clinical application prospect.

关 键 词：磁外科 磁压榨技术 磁吻合 食管吻合 实验研究 

分 类 号：R655.4[医药卫生—外科学]