基于内痈理论治疗活动期湿热毒证溃疡性结肠炎的疗效观察及其对炎性因子的影响  

Observation on Curative Effect of Active Ulcerative Colitis with Damp-Heat-Toxin Syndrome Treated from Internal Carbuncle Theory and Effects on Inflammatory Factors

作　　者：何巧飞 何飞龙 张永力 徐秋霞 HE Qiaofei;HE Feilong;ZHANG Yongli;XU Qiuxia(Department of Gastroenterology,Integrated Chinese and Western Medicine Hospital of Jinshan District,Shanghai 201501)

机构地区：[1]上海市金山区中西医结合医院消化内科,上海201501

出　　处：《中国中医药科技》2022年第1期5-8,共4页Chinese Journal of Traditional Medical Science and Technology

基　　金：上海市金山区科学技术委员会课题(2020-3-41)

摘　　要：目的:探讨基于内痈理论治疗活动期湿热毒证溃疡性结肠炎(UC)的临床疗效及对炎性因子的影响。方法:60例活动期湿热毒证UC患者随机分为观察组和对照组,各30例。对照组给予对症支持治疗,并给予美沙拉嗪肠溶片治疗4周,观察组在此基础上从痈论治,疗程为4周。比较两组患者近期临床疗效、肠镜表现及炎性因子(IL-2、IL-6、TNF-α)表达的变化。结果:观察组的临床疗效显著优于对照组(P <0.05);两组治疗后肠镜下表现均明显改善,观察组脓血糜烂、黏膜溃疡比例较对照组显著降低(P<0.05);治疗后,观察组血清IL-2水平明显升高,IL-6、TNF-α水平明显降低,且与对照组比较,差异均有统计学意义(P <0.05)。结论:在西医基础上联合内痈理论治疗活动期湿热毒证UC疗效显著,不仅可快速缓解临床症状,还能有效改善肠黏膜病理变化,减轻炎性反应。Objective:To explore on the curative effect of active ulcerative colitis( UC) with damp heat toxin syndrome treated from internal carbuncle theory and effects on inflammatory factors.Methods:60 Patients with active UC with damp heat toxin syndrome were randomly divided into observation group( 30 cases) and control group( 30 cases).The control group was given symptomatic support therapy and Mesalazine enteric-coated tablets for 4 weeks.On this basis,the observation group was treated with Chinese herbs from the internal carbuncle theory for 4 weeks.The short-term clinical efficacy,colonoscopy and changes of inflammatory factors were compared between the two groups.Results:The clinical efficacy of the observation group was significantly better than that of the control group( P < 0.05).After treatment,the endoscopic manifestations in both groups were significantly improved,and the proportion of abscess and erosion,mucosal ulcer in the observation group was significantly lower than that in the control group( P < 0.05).After treatment,serum IL-2 levels in the observation group were significantly increased,while IL-6 and TNF-α levels were significantly decreased,and the differences were significant compared with the control group( P < 0.05).Conclusion:The treatment from the internal carbuncle theory combined with Western medicine for active UC with damp heat toxin syndrome can not only relieve clinical symptoms,but also effectively improve intestinal mucosal pathological changes and reduce inflammatory reaction.

关 键 词：活动期溃疡性结肠炎 湿热毒证 以痈论治 白细胞介素-2 白细胞介素-6 肿瘤坏死因子 

分 类 号：R259[医药卫生—中西医结合]