microRNA在心搏骤停后脑损伤中的研究进展  

Research progress of microRNA in brain injury after cardiac arrest

作　　者：王静(综述)[1] 谢吐秀(审校) 吕菁君(审校)[1] Wang Jing;Xie Tuxiu;Lyu Jingjun(Department of Emergency,Renmin Hospital of Wuhan University,Hubei Province,Wuhan 430060,China;不详)

机构地区：[1]武汉大学人民医院急诊科,430060

出　　处：《疑难病杂志》2022年第1期98-101,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金项目(81372020);国家重点研发计划项目(2020YFC0846600)。

摘　　要：目的microRNA(miRNA)在心搏骤停(CA)后脑损伤的发生、发展过程中具有重要作用。一方面,miRNA作为一种新的理想生物标志物,可很好地预测CA后脑损伤的治疗和预后;另一方面,miRNA还参与调控CA后脑损伤过程中的炎性反应、氧化应激和细胞凋亡等。现就miRNA概述、CA后脑损伤概述和miRNA在CA后脑损伤中的作用及调控机制进行综述,为探寻新的预测和治疗CA后脑损伤的靶点提供依据。MicroRNA(miRNA)plays an important role in the occurrence and development of brain damage after cardiac arrest(CA).On the one hand,miRNA,as a new ideal biomarker,can well predict the treatment and prognosis of brain injury after CA.On the other hand,miRNA is also involved in the regulation of inflammatory response,oxidative stress and cell apoptosis in the process of brain injury after CA.This article summarizes the overview of miRNA,the overview of brain damage after CA,and the role and regulation mechanism of miRNA in brain damage after CA,to provide a basis for exploring new targets for predicting and treating brain damage after CA.

关 键 词：心搏骤停 脑损伤 MICRORNA 研究进展 

分 类 号：R541.78[医药卫生—心血管疾病] R651.15[医药卫生—内科学]