硒酵母联合维生素D对不同年龄分层的桥本甲状腺炎患者甲状腺相关抗体水平的影响  

Effect of selenium yeast combined with vitamin D on thyroid-associated antibody levels in patients with Hashimoto thyroiditis at different ages

作　　者：谷巍[1] 侯丽萍[1] 李晓龙 耿建林[1] GU Wei;HOU Liping;LI Xiaolong;GENG Jianlin(Department of Endocrinology,Halison International Peace Hospital,Hengshui 053000,China)

机构地区：[1]哈励逊国际和平医院内分泌科,河北衡水053000

出　　处：《内科理论与实践》2021年第6期392-396,共5页Journal of Internal Medicine Concepts & Practice

基　　金：2018年度河北省医学科学研究重点课题计划项目(项目编号20181595)。

摘　　要：目的:探讨硒酵母联合维生素D在不同年龄分层的桥本甲状腺炎(Hashimoto thyroiditis,HT)患者甲状腺相关抗体水平的影响。方法:选择2017年12月—2019年12月于我院内分泌科就诊的HT患者148例(成年患者96例,未成年患者52例)作为研究对象,联合治疗前对患者血清25-羟维生素[25-hydroxyvitamin D_(3),25(OH)D_(3)]水平进行检测,随机数字表法将患者分为对照组和观察组。对照组患者采用常规的治疗方法,观察组患者在其基础上使用硒酵母联合维生素D,经6个月治疗后,比较2组患者治疗前后甲状腺过氧化物酶自身抗体(thyroid peroxidase autoantibody,TPOAb)及甲状腺球蛋白抗体(thyroglobulin antibody,TgAb)水平及疗效。结果:成年患者和未成年患者治疗前25(OH)D_(3)水平均较参考范围偏低,但未成年患者高于成年患者(P<0.05)。成年患者和未成年患者联合治疗前对照组和观察组TPOAb以及TgAb水平差异无统计学意义(P>0.05),经6个月治疗后观察组TPOAb和TgAb水平显著低于对照组(P<0.05),同时观察组患者治疗效果显著高于对照组(P<0.05)。结论:对HT患者在常规治疗基础上应用硒酵母联合维生素D可以有效降低成年和未成年患者的TPOAb和TgAb水平,疗效显著,值得临床推广应用。Objective To investigate the effect of selenium yeast combined with vitamin D on thyroid related antibody levels in Hashimoto thyroiditis(HT)patients at different ages.Method In this study,148 patients with HT(96 adults and52 minors)were selected from December 2017 to December 2019.The patients were divided into control group and obser-vation group.The patients in the control group were treated with routine methods and the observation group of patients used selenium yeast and vitamin D besides routine treatment.After 6 months,the levels of thyroid peroxidase autoantibody(TPOAb)and thyroglobulin antibody(TgAb)before and after treatment were compared between two groups.Results Serum25-hydroxyvitamin D_(3)[25(OH)D_(3)]levels were detected in both adults and minors before combined treatment.The average 25(OH)D_(3) level in 2 groups before treatment was lower than normal,while the 25(OH)D_(3) level in minors was higher than that in adults(P<0.05).There was no significant difference in TPOAb and TgAb in control group and the observation group before treatment(P>0.05).The levels of TPOAb and TgAb in the observation group were significantly lower than those in the control group(P<0.05),in addition,the treatment effect of the observation group was significantly higher than that of the control group(P<0.05).Conclusions The treatment of HT with selenium yeast combined with vitamin D on the basis of routine treatment can effectively reduce the TPOAb and TgAb level in adult and minor patients.The therapeutic effect is remarkable and has application value in the clinic.

关 键 词：硒酵母 维生素D 年龄分层 桥本甲状腺炎患者 甲状腺过氧化物酶自身抗体 甲状腺球蛋白抗体 

分 类 号：R581.4[医药卫生—内分泌]