西沙群岛软珊瑚Lemnalia sp.倍半萜类次级代谢产物研究  

Sesquiterpenoids from a Xisha soft coral Lemnalia sp.

作　　者：刘明钰 韩晓晖 唐旭利[2] 李平林[1] 李国强[1] LIU Ming-yu;HAN Xiao-hui;TANG Xu-li;LI Ping-lin;LI Guo-qiang(Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;College of Chemistry and Chemical Engineering,Ocean University of China,Qingdao 266100,China)

机构地区：[1]中国海洋大学海洋药物教育部重点实验室,医药学院,山东青岛266003 [2]中国海洋大学化学化工学院,山东青岛266100

出　　处：《中国海洋药物》2021年第6期44-48,共5页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金面上项目(41876161)资助。

摘　　要：目的对西沙群岛软珊瑚样品Lemnalia sp.进行萜类次级代谢产物的化学结构研究。方法利用薄层色谱、硅胶柱层析、高效液相色谱和中压制备液相色谱等分离手段对软珊瑚提取物中的化合物进行分离、纯化;运用核磁共振、质谱等现代波谱学方法,通过与报道的数据进行对比,对化合物的化学结构进行鉴定。结果从西沙群岛软珊瑚Lemnalia sp.中分离鉴定10个倍半萜类化合物,分别为4-acetoxy-2,8-neolemnadien-5-one(1)、paralemnolinE(2)、paralemnolinH(3)、paralemnolinL(4)、paralemnolinJ(5)、2-deoxy-7-O-methyllemnacarnol(6)、parathyrsoidinD(7)、(1a S,4S,4a S,5S,8a R)-5-acetyl-4,4a-dimethyloctahydro-6Hnaphtho[1,8a-b]oxiren-6-one(8)、paralemnolin K(9)和paralemnolin P(10)。结论从软珊瑚Lemnalia sp.中分离得到10个已知的倍半萜类化合物,化学结构类型分别属于neolemnane型、nardosinane型和nornardosinane型,其中,化合物2~10为首次从Lemnalia属软珊瑚中得到。Objective Investigating the chemical structures of sesquiterpenoids isolated from a soft coral Lemnalia sp. collected from the Xisha Islands. Methods A variety of chromatographic separation techniques were used to isolate secondary metabolites, including TLC, silica gel column chromatography, HPLC, and MPLC. Various modern spectroscopy technologies(NMR spectroscopy, MS, etc.) and comparison with the reported data were carried out to identify the structures of the compounds. Results Ten sesquiterpenoids were isolated from Lemnalia sp. and were identified as 4-acetoxy-2,8-neolemnadien-5-one(1), paralemnolin E(2), paralemnolin H(3), paralemnolin L(4), paralemnolin J(5), 2-deoxy-7-O-methyllemnacarnol(6),parathyrsoidin D(7),(1 a S,4 S,4 a S,5 S,8 a R)-5-acetyl-4,4 a-dimethyloctahydro-6 H-naphtho[1,8 a-b]oxiren-6-one(8), paralemnolin K(9) and paralemnolin P(10). Conclusion Ten known sesquiterpenoids with neolemnane,nardosinane, and nornardosinane-type skeletons, were isolated from the soft coral Lemnalia sp. Compounds 2~10 were obtained from soft corals of the genus Lemnalia for the first time.

关 键 词：Lemnalia sp. 次级代谢产物 倍半萜 结构鉴定 

分 类 号：R931.77[医药卫生—生药学]