Meyerson痣6例临床及病理分析  

Clinical and pathological analysis of six cases of Meyerson nevi

作　　者：陈凤鸣[1] 刘玲[1] 付萌[1] 王雷[1] 高天文[1] Chen Fengming;Liu Ling;Fu Meng;Wang Lei;Gao Tianwen(Department of Dermatology,The Fourth Military Medical University,Xi′an 710032,China)

机构地区：[1]第四军医大学西京皮肤医院,西安710032

出　　处：《中华皮肤科杂志》2022年第1期47-50,共4页Chinese Journal of Dermatology

摘　　要：目的探讨Meyerson痣临床及组织病理特征。方法回顾性分析2015年1月至2020年1月第四军医大学西京皮肤医院确诊的6例Meyerson痣患者临床及病理资料。结果6例患者中,男3例,女3例,年龄7个月至28岁,中位年龄10.5岁。3例皮损位于四肢,3例位于躯干。4例发生于先天性色素痣,2例发生于获得性色素痣。色素痣出现时长7个月至18年。4例近2个月自觉瘙痒,2例无瘙痒等伴随症状。中央色素痣形态为丘疹5例,斑块1例,形状规则,皮损颜色为褐色或黑色,色素均匀,边界清楚。6例色素痣周围均可见红晕,4例皮损上覆鳞屑或痂皮。组织病理学表现出色素痣及湿疹的双重特点,色素痣表现为交界痣或混合痣,湿疹表现为浆液渗出,表皮不规则增生,海绵水肿,真皮浅层血管周围淋巴细胞浸润。结论Meyerson痣少见,好发于躯干及四肢,当色素痣出现瘙痒或皮损周围出现红斑时,应考虑Meyerson痣的可能。Objective To investigate clinical and histopathological features of Meyerson nevus.Methods Clinical and histopathological data were collected from 6 patients with confirmed Meyerson nevi in Department of Dermatology,the Fourth Military Medical University from January 2015 to January 2019,and retrospectively analyzed.Results Among the 6 patients,3 were males and 3 were females,with a median age of 10.5 years(range,7 months to 28 years).Skin lesions were located on the extremities of 3 cases,as well as on the trunk of 3 cases.Meyerson nevi arose from congenital pigmented nevi in 4 cases,as well as from acquired pigmented nevi in 2 cases.The duration of pigmented nevi varied from 7 months to 18 years.Four patients felt itching in the past 2 months,and 2 had no concomitant symptoms such as itching.Central pigmented nevi manifested as papules in 5 cases and a plaque in 1 case,which were brown or black in color,with regular shapes,uniform pigmentation and clear borders.Pigmented nevi were surrounded by a halo of erythema in 6 cases,and skin lesions were covered with scales or crusts in 4 cases.Histopathological examination of Meyerson nevi revealed characteristics of both pigmented nevus and eczema.Histopathologically,pigmented nevi manifested as junctional nevi or compound nevi,and eczema manifested as serous exudation,irregular epidermal hyperplasia,spongiosis and perivascular infiltration of lymphocytes in the superficial dermis.Conclusions Meyerson nevus is rare,and mostly occurs on the trunk and extremities.When itching occurs or erythema appears around the pigmented nevus,the diagnosis of Meyerson nevus should be considered.

关 键 词：痣 色素 湿疹 Meyerson痣 

分 类 号：R758.51[医药卫生—皮肤病学与性病学]