长脉宽1064nm Nd:YAG激光联合含滇山茶和三七等提取物的外用乳剂治疗黄褐斑的疗效  

Efficacy of long-pulsed 1064-nm Nd:YAG laser combined with a topical emulsion containing Camellia reticulata and Radix Notoginseng in the treatment of melasma

作　　者：郭静[1] 杨景煜 丁黎[1] 刘明明 侯晶梅 蒲小霞 孙嘉昱 李向花[1] Guo Jing;Yang Jingyu;Ding Li;Liu Mingming;Hou Jingmei;Pu Xiaoxia;Sun Jiayu;Li Xianghua(Department of Dermatology,People′s Hospital of Ningxia Hui Autonomous Region,The First Clinical Medical College of Northwest University for Nationalities,Candidate Branch of National Clinical Research Center for Skin Diseases,Yinchuan 750002,China)

机构地区：[1]宁夏回族自治区人民医院,西北民族大学第一临床学院皮肤科,国家皮肤与免疫疾病临床医学研究中心分中心,银川750002

出　　处：《中华皮肤科杂志》2022年第1期61-64,共4页Chinese Journal of Dermatology

摘　　要：目的评估长脉宽1064 nm Nd:YAG激光联合含滇山茶和三七的外用乳剂治疗黄褐斑的疗效。方法选取2019年6月至2020年6月宁夏回族自治区人民医院皮肤科门诊收治的80例黄褐斑患者,按随机数字表法随机分为对照组和观察组。对照组40例,采用长脉宽1064 nm Nd:YAG激光治疗,每2周1次,6次为1个疗程;观察组40例,在对照组治疗的基础上联合外用含滇山茶和三七的外用乳剂,每天2次,3个月为1个疗程。比较两组治疗前后黄褐斑皮损面积和严重度指数(MASI)、临床疗效、患者满意度以及安全性。结果观察组治疗后4周、8周MASI评分分别为(14.57±3.22)分、(10.00±2.94)分,对照组为(14.74±3.11)分、(11.31±3.00)分,两组差异均无统计学意义(P>0.05)。治疗后12周,观察组MASI评分为(4.80±2.78)分,对照组(7.07±3.22)分,两组差异有统计学意义(t=-3.38,P<0.01)。治疗后3个月观察组有效36例(90%),对照组31例(77.5%),组间差异有统计学意义(χ^(2)=4.58,P<0.001);患者满意度87.5%,对照组72.5%,两组差异无统计学意义(χ^(2)=7.26,P=0.06)。观察组不良反应发生率12.5%(5例),对照组为17.5%(7例),两组差异无统计学意义(P>0.05)。结论联合外用含滇山茶和三七的外用乳剂比单用长脉宽1064 nm Nd:YAG激光治疗黄褐斑皮损改善更明显,患者满意度更高,且不良反应发生率降低。Objective To evaluate the efficacy of long-pulsed 1064-nm Nd:YAG laser combined with a topical emulsion containing Camellia reticulata and Radix Notoginseng in the treatment of melasma.Methods A total of 80 patients with melasma were enrolled from Department of Dermatology,People′s Hospital of Ningxia Hui Autonomous Region from June 2019 to June 2020,and randomly and equally divided into control group and observation group by using a random number table:40 patients in the control group were treated with long-pulsed 1064-nm Nd:YAG laser once every 2 weeks for 6 sessions as a course of treatment;another 40 in the observation group were treated with the same laser therapy as the control group and a topical emulsion containing Camellia reticulata and Radix Notoginseng twice a day for 3 months as a course of treatment.Melasma area and severity index(MASI),clinical efficacy,patient satisfaction rate and safety were compared between the 2 groups before and/or after treatment.Results After 4-and 8-week treatment,there was no significant difference in the MASI score between the observation group(14.57±3.22 points,10.00±2.94 points,respectively)and control group(14.74±3.11 points,11.31±3.00 points,respectively;both P>0.05).After 12-week treatment,the MASI score was significantly lower in the observation group(4.80±2.78 points)than in the control group(7.07±3.22 points,t=-3.38,P<0.01).After 3-month treatment,the response rate was significantly higher in the observation group(36 cases,90%)than in the control group(31 cases,77.5%;χ^(2)=4.58,P<0.001);however,there was no significant difference in the patient satisfaction rate between the observation group(87.5%)and control group(72.5%,χ^(2)=7.26,P=0.06).In addition,no significant difference in the occurrence of adverse reactions was observed between the observation group(5 cases,12.5%)and control group(7 cases,17.5%;P>0.05).Conclusion Compared with the long-pulsed 1064-nm Nd:YAG laser alone,the topical emulsion containing Camellia reticulata and Radix Notoginseng in

关 键 词：黄褐斑 激光疗法 治疗结果 长脉宽1064nm Nd:YAG激光 滇山茶 三七 联合治疗 

分 类 号：R275.9[医药卫生—中西医结合]