冬凌草中1个新的对映-贝壳杉烷二萜  

A new ent-kaurane diterpenoid from Isodon rubescens

作　　者：刘旭[1,3] 陈春霞[2,3] 吴继洲 LIU Xu;CHEN Chun-xia;WU Ji-zhou(Department of Pharmacy,Tongji Hospital,Tongji Medical College Huazhong University of Science and Technology,Wuhan 430040,China;Wuhan Vocational College of Software and Engineering,Wuhan 430070,China;College of Pharmacy,Tongji Medical College Huazhong University of Science and Technology,Wuhan 430040,China)

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,湖北武汉430040 [2]武汉软件工程职业学院,湖北武汉430070 [3]华中科技大学同济医学院药学院,湖北武汉430040

出　　处：《中草药》2021年第23期7083-7087,共5页Chinese Traditional and Herbal Drugs

基　　金：湖北省自然科学基金(2020CFB616)。

摘　　要：目的研究鄂西地区产冬凌草Isodon rubescens的化学成分。方法采用多种柱色谱法进行分离纯化,并经波谱分析鉴定化合物的结构。结果从湖北建始县产冬凌草的乙醇浸提物中,分离鉴定出6个对映-贝壳杉烷二萜,分别为3β,6β,14β,15β-四乙酰氧基-20-醛-对映-贝壳杉-16-烯-7-酮(1)、川藏香茶菜素O(2)、enmenin(3)、enmenin monoacetate(4)、乙酰化毛萼晶F(5)、荛花香茶菜乙素(6)。结论化合物1为1个新化合物,命名为建始冬凌草素J,为香茶菜属植物极为少见的一类型对映-贝壳杉二萜,结构特点为C-20氧化为醛基而未与C-3、C-7、C-11形成常见的环氧桥结构。化合物2 和4为首次从该植物中分离得到。Objective To investigate the chemical constituents from Isodon rubescens collected in the west of Hubei Province.Methods Various column chromatography techniques were used to isolate and purify the compounds and their structures were identified by spectral data. Results From ethanol extract of plants in Jinshi County, six ent-kaurene diterpenoids were isolated and identified, of which one new compound 3β,6β,14β,15β-tetracetoxy-20-aldehyde-ent-kaur-16-en-7-one(1), and other known ones as pharicin O(2), enmenin(3), enmenin monoacetate(4), acetonide of maoyecrystal F(5), and wikstroenioidin B(6). Conclusion The new compound 1 named as jianshirubesin J is identified as a rare ent-kaurane diterpenoid in genus Isodon for its oxygenated C-20 as an aldehyde instead of a common epoxy-bridge with C-3, C-7, or C-11. And compound 2 and 4 are isolated from this plant for the first time.

关 键 词：冬凌草 对映-贝壳杉烷 二萜 建始冬凌草素J 川藏香茶菜素O 荛花香茶菜乙素 

分 类 号：R284.1[医药卫生—中药学]