白花败酱的化学成分研究  

Chemical constituents of Patrinia villosa

作　　者：黄乐怡 孙煜铮 陈倩倩 杜婷婷 许红涛 侴桂新 HUANG Le-yi;SUN Yu-zheng;CHEN Qian-qian;DU Ting-ting;XU Hong-tao;CHOU Gui-xin(Shanghai University of Traditional Chinese Medicine,Institute of Chinese Materia Medica,Shanghai R&D Centre for Standardization of Chinese Medicines,Shanghai 200000,China)

机构地区：[1]上海中医药大学中药研究所,上海中药标准化研究中心,上海200000.

出　　处：《中草药》2021年第23期7088-7095,共8页Chinese Traditional and Herbal Drugs

基　　金：重大新药创制基金(2019ZX09735-002)。

摘　　要：目的研究白花败酱Patrinia villosa全草的化学成分。方法采用硅胶、ODS、Sephadex-LH 20凝胶、制备等多种色谱分离技术进行分离纯化,然后通过波谱数据分析进行结构鉴定。结果从白花败酱95%乙醇提取物中分离得到28个化合物,分别鉴定为去甲络石藤苷元(1)、salicifoliol(2)、pinoresinol(3)、matairesinol(4)、epipinoresinol(5)、boehmenan(6)、(+)-dehydrovomifoliol(7)、(3S,5R,6S,7E)-3,5,6-trihydroxy-7-megastigmen-9-one(8)、loliolide(9)、9-hydroxy-4,6-megastigmadien-3-one(10)、scopoletin(11)、咖啡酸乙酯(12)、5,7-二羟基-4′-甲氧黄酮醇(13)、7-ketositosterol(14)、5α,8α-epidioxyergosta-6,22-dien-3β-ol(15)、stigmast-4-ene-6α-ol-3-one(16)、stigmast-4-ene-3,6-diol(17)、2,2′-oxybis(1,4)-di-tertbutylbenzene (18)、 kaempferol (19)、 p-hydroxybenzaldehyde (20)、 2′-O-(9Z,12Z,15Z-octadecatrienoyl)glyceryl-β-Dgalactopyranoside(21)、protocatechualdehyde(22)、对香豆酸(23)、对羟基苯甲酸(24)、5-hydroxy-4-(4-hydroxyphenyl)-2(5H)-furanone hydroxybutenolide(25)、马栗树皮素(26)、绿原酸(27)、绿原酸甲酯(28)。结论化合物1、2、4~6、8、10~26、28为首次从白花败酱中分离得到。Objective To study the chemical constituents from the whole plants of Patrinia villosa. Methods Chemical constituents were isolated and purified with the help of various chromatographic techniques such as silica gel, ODS, Sephadex-LH 20, Pre-HPLC. The structures of these compounds were identified by spectral data analysis. Results Twenty-eight compounds were separated from the ethanol extract of P. villosa, which were identified as nortrachelogenin(1), salicifoliol(2), pinoresinol(3),matairesinol(4), epipinoresinol(5), boehmenan(6),(+)-dehydrovomifoliol(7),(3 S,5 R,6 S,7 E)-3,5,6-trihydroxy-7-megastigmen-9-one(8), loliolide(9), 9-hydroxy-4,6-megastigmadien-3-one(10), scopoletin(11), caffeic acid ethyl ester(12), 5,7-dihydroxy l-4′-methoxyl flavonol(13), 7-ketositosterol(14), 5α,8α-epidioxyergosta-6,22-dien-3β-ol(15), stigmast-4-ene-6α-ol-3-one(16),stigmast-4-ene-3,6-diol(17), 2,2′-oxybis(1,4)-di-tert-butylbenzene(18), kaempferol(19), p-hydroxybenzaldehyde(20),2′-O-(9 Z,12 Z,15 Z-octadecatrienoyl) glyceryl β-D-galactopyranoside(21), protocatechualdehyde(22), p-coumaric acid(23),p-hydroxybenzoic acid(24), 5-hydroxy-4-(4-hydroxyphenyl)-2(5 H)-furanone hydroxybutenolide(25), 6,7-dihydroxy-coumarin(26),chlorogenic acid(27), and methyl chlorogenate(28). Conclusion Compounds 1, 2, 4, 5, 6, 8, 10—26, and 28 are isolated from P.villosa for the first time.

关 键 词：白花败酱 去甲络石藤苷元 咖啡酸乙酯 马栗树皮素 绿原酸甲酯 

分 类 号：R284.1[医药卫生—中药学]