内皮功能失调与泛血管疾病  

Endothelial dysfunction and panvascular diseases

作　　者：徐索文 葛均波 翁建平 XU Suowen;GE Junbo;WENG Jianping(Department of Endocrinology,The First Affiliated Hospital of USTC(Anhui Provincial Hospital),Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China;Department of Cardiology,The First Affiliated Hospital of USTC(Anhui Provincial Hospital),Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China;Department of Cardiology,Institute of Panvascular Medicine,Zhong Shan Hospital,Fudan University,Shanghai Institute of Cardiovascular Diseases,Shanghai 200032,China)

机构地区：[1]中国科学技术大学生命科学与医学部,中国科学技术大学附属第一医院(安徽省立医院)内分泌科,安徽合肥230001 [2]中国科学技术大学生命科学与医学部,中国科学技术大学附属第一医院(安徽省立医院)心内科,安徽合肥230001 [3]复旦大学附属中山医院心内科,复旦大学泛血管医学研究院,上海心血管病研究所,上海200032

出　　处：《中国科学技术大学学报》2021年第8期577-585,共9页JUSTC

基　　金：国家自然科学基金(81941022,81530025,82070464);中国科学院战略性先导科技专项B类(XDB38010100);国家重点研发计划 (2017YFC1309603);广东省“珠江人才计划”本土创新科研团队(2017BT01S131);中国科学技术大学附属第一医院创新攻关团队项目(CXGG02);安徽省重点研究与开发计划 (202104j07020051)资助

摘　　要：血管内皮细胞是机体维持血管健康和稳态的关键细胞类型.内皮细胞功能失调(endothelial dysfunction,ED)作为泛血管疾病(panvascular diseases)的核心环节,是一个多步骤、多危险因素参与的复杂病理过程,涉及内皮细胞损伤死亡、通透性的增加、血管收缩、炎症、氧化应激、白细胞向内皮细胞的黏附、代谢异常、内皮-间充质转变、血小板聚集与血栓形成等.ED在心血管疾病(动脉粥样硬化、高血压、心衰、外周血管病变)、肿瘤、代谢性疾病(糖尿病、肥胖、胰岛素抵抗、脂肪肝)、呼吸系统疾病(急性肺损伤、肺动脉高压等)、病毒感染(COVID-19)等的发生发展过程中都扮演着重要角色.因此,血管内皮功能评价对于临床诊疗有重要的意义.本文以ED与泛血管疾病的关系为切入点,综述近5年来内皮细胞功能在泛血管疾病中的研究进展,旨在阐明泛血管疾病的最新分子机制,加速靶向ED的泛血管药学的发展.Vascular endothelial cells are the key cell type responsible for vascular health and homeostasis.Endothelial dysfunction(ED),as the core process of panvascular diseases,is caused by multi-step and multi-risk factors involving endothelial injury,hyperpermeability,vasoconstriction,inflammation,oxidative stress,leukocyte adhesion,metabolic disorder,endothelial-to-mesenchymal transition(EndMT),and platelet activation.ED plays an important role in cardiovascular,tumor,metabolic,pulmonary,and infectious diseases.Therefore,the assessment of endothelial function is of great importance to clinical diagnosis and therapeutics.In this review,we centered on the relationship between ED and panvascular diseases,and overviewed the research advance of ED and panvascular diseases,with an aim to understanding the novel molecular mechanism of panvascular diseases and accelerating the development of pharmaceuticals targeting ED in panvascular diseases.

关 键 词：泛血管疾病 泛血管医学 内皮功能失调 血管稳态 综述 

分 类 号：R54[医药卫生—心血管疾病]