脂肪乳剂使用剂量对极低出生体重儿体格增长及安全性的影响  

Effect of Fat Emulsion Dosage on Physical Growth and Safety of Very Low Birth Weight Infants

作　　者：郭丹苗 余兆聪 梁蔼坚 慕容三群 Guo Dan-miao;Yu Zhao-cong;Liang Ai-jian;Murong San-qun(Department of Pediatrics,People's Hospital of Gaoyao District of Zhaoqing City,Zhaoqing 526000,Guangdong Province,China)

机构地区：[1]广东省肇庆市高要区人民医院儿科,广东肇庆526000

出　　处：《中国社区医师》2022年第2期37-39,共3页Chinese Community Doctors

摘　　要：目的:分析脂肪乳剂使用剂量对极低出生体重儿(VLBWI)体格增长及安全性的影响。方法:2017年1月-2020年12月收治VLBWI患儿100例,随机分为两组,各50例。对照组出生24 h内首次给予多种油脂肪乳注射液0.5 g/(kg·d),以0.5 g/(kg·d)的剂量逐日递增;观察组出生24 h内首次给予多种油脂肪乳注射液1.0 g/(kg·d),以1.0 g/(kg·d)的剂量每日递增。比较两组患儿血浆甘油三酯水平、体格增长情况及并发症发生率。结果:观察组出生第7天血甘油三酯水平低于对照组,差异有统计学意义(P<0.05)。观察组体重日增量及出院时体重均高于对照组,体重下降最大值小于对照组,差异有统计学意义(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:VLBWI患儿使用高剂量脂肪乳,可促进体格增长,且不会增加并发症发生率。Objective:To analyze the effect of dosage of fat emulsion on physical growth and safety of very low birth weight infants(VLBWI).Methods:From January 2017 to December 2020,100 VLBWI were randomly divided into two groups with 50 cases in each group.The control group was given 0.5 g/(kg·d)of multi-oil fat emulsion injection for the first time within 24 hours of birth,increasing daily at the dose of 0.5 g/(kg·d).The observation group was given 1.0 g/(kg·d)of multi-oil fat emulsion injection for the first time within 24 hours of birth,increasing daily at the dose of 1.0 g/(kg·d).The levels of plasma triacylglycerol,physical growth and the incidence of complications were compared between the two groups.Results:In the observation group,the level of blood triacylglycerol on the 7th day of birth was lower than that in the control group,the difference was statistically significant(P<0.05).In the observation group,the daily increment of body mass and body mass at discharge were higher than those in the control group,and the maximum decline of body mass was lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:The use of high-dose fat emulsion in VLBWI can promote physical growth without increasing the incidence of complications.

关 键 词：脂肪乳剂 极低出生体重儿 体格增长 安全性 

分 类 号：R722.6[医药卫生—儿科]