益生菌治疗溃疡性结肠炎患者的临床效果  

Clinical Effect of Probiotics in the Treatment of Ulcerative Colitis

作　　者：李秀丽[1] 张玉凤[1] LI Xiuli;ZHANG Yufeng(Department of Gastroenterology,The 79th Group Military Hospital of the Chinese People's Liberation Army Army,Liaoyang 111000,China)

机构地区：[1]中国人民解放军陆军第79集团军医院消化内科,辽宁辽阳111000

出　　处：《中国医药指南》2022年第5期113-115,共3页Guide of China Medicine

摘　　要：目的分析溃疡性结肠炎疾病特点,评价溃疡性结肠炎疾病治疗中联合益生菌治疗的可行性与效果,为溃疡性结肠炎的治疗工作提供参考。方法选择医院2018年1月至2019年5月收治住院治疗的溃疡性结肠炎患者74例,按照随机数表法进行分组治疗。对照组37例患者采取美沙拉嗪治疗,试验组37例患者配合益生菌治疗。对比对照组与试验组溃疡性结肠炎患者的治疗情况,包括预后效果、用药安全情况、复发率情况、病情恢复情况以及肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、白细胞介素-10(IL-10)等炎性细胞因子水平变化情况。结果两组患者组间用药安全性比较,P>0.05;试验组患者治疗后总有效率高于对照组,P<0.05;试验组患者6个月后复发率低于对照组,P<0.05;两组患者治疗后溃疡性结肠炎疾病活动指数、临床症状积分较治疗前下降,且试验组患者均明显低于对照组,P<0.05;两组患者治疗后的TNF-α、IL-2较治疗前下降,IL-10较治疗前提升,试验组患者的改善情况更佳,P<0.05。结论溃疡性结肠炎疾病行美沙拉嗪联合益生菌治疗可促进患者病情、炎性细胞因子水平的改善,且治疗效果显著、安全性高。Objective To analyze the characteristics of ulcerative colitis disease,evaluate the feasibility and effect of combined probiotic therapy in the treatment of ulcerative colitis disease,and provide a reference for the treatment of ulcerative colitis.Methods Selected 74 patients with ulcerative colitis admitted to our hospital from January 2018 to May 2019 for treatment in groups according to the random number table method,37 patients in the control group were treated with mesalazine,and 37 patients in the test group were treated with probiotics.Compare the treatment of patients with ulcerative colitis in the control group and the test group,including the prognostic effect,drug safety,recurrence rate,condition,and tumor necrosis factor-α(TNF-α)and interleukin-2(IL-2),interleukin-10(IL-10)changes in the levels of inflammatory cytokines.Results Comparison of drug safety between the two groups of patients,P>0.05;the total effective rate of patients in the experimental group after treatment is higher than that of the control group,P<0.05;the recurrence rate of patients in the experimental group after 6 months is lower than that of the control group,P<0.05.After treatment,ulcerative colitis disease activity index and clinical symptom score of the patients in the experimental group were significantly lower than those in the control group,P<0.05;the TNF-αand IL-2 of the two groups of patients after treatment were lower than those before the treatment,IL-10 increased compared with that before treatment,and the improvement of patients in the experimental group was better,P<0.05.Conclusion Mesalazine alone is generally effective in the treatment of ulcerative colitis.The combination of probiotics can promote the improvement of the patient's condition and the level of inflammatory cytokines.

关 键 词：溃疡性结肠炎 益生菌 安全性 炎性细胞因子 复发 

分 类 号：R516.1[医药卫生—内科学]