高龄女性单囊胚冷冻复苏周期中囊胚腔大小及孵化程度对妊娠及出生结局的影响  

Effect of blastocyst size and incubation degree on the pregnancy and birth outcomes during cryopreservation cycle of single blastocyst in elderly women

作　　者：刘双 程东凯[1] 于洪君[1] 李宝山[1] LIU Shuang;CHENG Dongkai;YU Hongjun;LI Baoshan(The Reproductive Laboratory,Shenyang Dongfang Jinghua Hospital,Shenyang,Liaoning 110005,China)

机构地区：[1]沈阳东方医疗集团菁华医院生殖实验室,辽宁沈阳110005

出　　处：《安徽医药》2022年第2期293-296,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析高龄女性单囊胚冷冻复苏周期中囊胚腔大小及孵化程度对妊娠结局及出生结局的影响。方法选择2014年1月至2017年12月于沈阳东方医疗集团菁华医院进行单囊胚冷冻复苏移植周期共4103个,根据囊胚腔大小和是否孵化将其分为4期囊胚、5期囊胚和6期囊胚。分别比较三组的囊胚复苏后的移植结局是否存在差异;之后对年龄>35岁亚组单独分析,分为4期囊胚、5期囊胚和6期囊胚并比较三组囊胚复苏后的移植、妊娠及出生结局。结果单囊胚冷冻复苏周期中囊胚腔大小及孵化程度在移植结局和出生结局各项指标中差异无统计学意义(P>0.05);年龄>35岁以上亚组中,4期囊胚临床妊娠率(48.35%比34.38%、36.59%)和活产率(32.94%比20.32%、19.51%)高于5期和6期,4期新生儿低出生体质量率小于5期和6期(5.03%比23.07%、12.5%),差异有统计学意义(P<0.05)。结论不分年龄段,单囊胚冷冻复苏周期囊胚腔大小及孵化程度对临床结局的影响差别不大,但在35岁以上女性单囊胚冷冻复苏周期中,4期囊胚移植后的妊娠结局及出生结局更佳。Objective To analyze the effect of blastocyst size and hatching degree on the pregnancy and birth outcomes in the cryo⁃preservation cycle of single blastocysts in elderly women.Methods A total of 4103 singlevesicle embryo cryopreservation transplantation cycles in Shenyang Oriental Green Reproductive Hospital from January 2014 to December 2017 were performed.According to the size of the blastocyst and whether it was hatched,it was assigned into 4 blastocysts,5 blastocysts and 6 blastocysts.The differences in the transplant outcomes of blastocysts after resuscitation of the three groups were compared.The age group>35 years old was analyzed separately and it was assigned into 4 blastocysts,5 blastocysts and 6 blastocysts and the transplant,pregnancy and birth outcomes of blastocysts after resuscitation in three groups were compared.Results The size and hatching degree of blastocysts in the single-vesicle embryo cryopreservation cycle were not significantly different between clinical outcomes and birth outcomes(P>0.05).In the subgroup of age>35 years old,the clinical pregnancy rate(48.35%vs.34.38%,36.59%)and live birth rate(32.94%vs.20.32%,19.51%)in stage 4 blastocysts were higher than those of stage 5 and stage 6.The neonatal low birth weight rate was less than stage 5 and stage 6(5.03%vs.23.07%,12.5%),and the difference was statistically significant(P<0.05).Conclusion Regardless of age group,the effect of blastocyst size and hatching on the clinical outcome of the single-vesicle embryo cryopreservation cycle is not significant,but in the single-blast embryo cryopreservation cycle of women over 35 years old,the pregnancy outcomes and birth outcomes after stage 4 blastocyst transfer are better.

关 键 词：单胚胎移植 冷冻 高龄女性 单囊胚 囊胚腔大小 孵化 

分 类 号：R714.8[医药卫生—妇产科学]