氧化应激对甲状腺癌的影响及中药单体体外干预的研究进展  

Research progress on effect of oxidative stress in thyroid cancer and intervention of Chinese medicine monomer in vitro

作　　者：汪晓露 赵勇[2] 左新河[2,3] 谢敏 付畅 WANG Xiaolu;ZHAO Yong;ZUO Xinhe;XIE Min;FU Chang(Clinical College of Traditional Chinese Medicine,Hubei University of Traditional Chinese Medicine,Wuhan,Hubei 430061,China;Center for Diagnosis and Treatment of Thyroid Diseases,Hubei Hospital of Traditional Chinese Medicine,Wuhan,Hubei 430074,China;First Clinical College,Hubei University of Traditional Chinese Medicine,Wuhan,Hubei 430061,China)

机构地区：[1]湖北中医药大学中医临床学院,湖北武汉430061 [2]湖北省中医院甲状腺疾病诊疗中心,湖北武汉430074 [3]湖北中医药大学第一临床学院,湖北武汉430061

出　　处：《上海中医药杂志》2021年第10期79-83,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局陈如泉全国名中医传承工作室建设项目(国中医药人教函〔2018〕119号);国家中医药管理局全国中医学术流派传承工作室第二轮建设项目(国中医药人教函〔2019〕62号)。

摘　　要：综述氧化应激对甲状腺癌的影响及中药单体体外干预的研究进展。氧化应激以矛盾的方式影响甲状腺癌的进程,既参与肿瘤的形成与发展,亦可导致癌细胞死亡;活性氧的累积参与甲状腺癌的发生和进展,亦可导致癌细胞的迁移与侵袭。小白菊内酯、淫羊藿苷、雷公藤甲素、藏红花素、青蒿琥酯、姜黄素、丹酚酸B、葛根素、紫草素等中药单体能引起体外甲状腺癌细胞内氧化性物质堆积,减少抗氧化酶生成,以此诱导甲状腺癌细胞凋亡等,从而发挥其治疗作用。The research progress on the effect of oxidative stress in thyroid cancer and intervention of Chinese medicine monomer in vitro were reviewed.Oxidative stress affected the process of thyroid cancer in a paradoxical way,it not only participated in the formation and development of tumors,but also led to the death of cancer cells;the accumulation of reactive oxygen species was involved in the occurrence and progression of thyroid cancer,which could also lead to the migration and invasion of cancer cells.There were some Chinese medicine monomers such as parthenolide,icariin,triptolide,crocin,artesunate,curcumin,salvianolic acid B,puerarin and shikonin could cause the accumulation of oxidative substances in thyroid cancer cells in vitro,reduce the production of antioxidant enzymes,thereby inducing the apoptosis of thyroid cancer cells,etc.,so as to exert its therapeutic effect.

关 键 词：氧化应激 甲状腺癌 细胞凋亡 中药单体 综述 

分 类 号：R273[医药卫生—中西医结合]