黄连清热通络方联合利拉鲁肽治疗肥胖2型糖尿病对患者氧化应激因子及脂联素的影响  

Effect of Huanglian Qingre Tongluo Recipe Combined with Lilaru Peptide on Oxidative Stress Factor and Adiponectin for Obese Type 2Diabetes Mellitus

作　　者：叶尧瑶 阮义生 翟春生 李霞 YE Yaoyao;RUAN Yisheng;ZHAI Chunsheng(The Eighth Peopled Hospital of Hefei City,Hefei Anhui 238000,China;Anhui Medical University,Hefei Anhui 238000,China)

机构地区：[1]合肥市第八人民医院,安徽合肥238000 [2]安徽医科大学,安徽合肥238000

出　　处：《四川中医》2021年第12期119-122,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察黄连清热通络方联合利拉鲁肽治疗肥胖2型糖尿病对患者氧化应激因子及脂联素的影响。方法:选取我院于2017年5月~2020年8月收治的肥胖2型糖尿病患者136例,根据治疗方法分为两组,每组68例。对照组给予利拉鲁肽治疗,观察组给予黄连清热通络方联合利拉鲁肽治疗。记录两组体质量指数(BMI)、腰围、血糖指标、氧化应激因子、脂联素及腹部脂肪体积的变化。结果治疗后,两组BMI、腰围、空腹血糖(FPG)、餐后2h血糖(2hPG)、胰岛素抵抗指数(HOMA-IR)较治疗前下降(P<0.05),观察组BMI、腰围、FPG、2hPG、HOMA-IR低于对照组(P<0.05)。治疗后,两组超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)、脂联素水平较治疗前上升(P<0.05),丙二醛(MDA)水平较治疗前下降(P<0.05),观察组SOD、T-AOC、脂联素水平高于对照组(P<0.05),MDA水平低于对照组(P<0.05)。治疗后,两组内脏脂肪体积、皮下脂肪体积及内脏脂肪体积/皮下脂肪体积较治疗前下降(P<0.05),观察组内脏脂肪体积、皮下脂肪体积及内脏脂肪体积/皮下脂肪体积低于对照组(P<0.05)。结论:黄连清热通络方联合利拉鲁肽治疗肥胖2型糖尿病可减少患者腹部脂肪体积,提高机体抗氧化能力,有效控制血糖和体质量指数。Objective: To observe the effect of Huanglian Qingre Tongluo Recipe combined with Lilaru Peptide on oxidative stress factor and adiponectin for obese type 2 diabetes mellitus.Methods: 136 obese type 2 diabetes patients admitted in our hospital from May 2017 to August 2020 were divided into two groups according to the treatment method, 68 cases in each group.The controlled group was treated with Lilaru Peptide, and the observation group was treated with Huanglian Qingre Tongluo Recipe combined with Lilaru Peptide.Changes of body mass index(BMI),waist circumference, blood glucose index, oxidative stress factor, adiponectin and abdominal fat volume were recorded.Results: The two groups of BMI,waist circumference, fasting blood glucose(FPG),postprandial blood glucose(2 hPG) and insulin resistance index(HOMA-IR) were lower than those before treatment(P<0.05).The waist circumference and FPG,2 hPG,HOMA-IR in the observation group were lower than those in the controlled group(P<0.05).The levels of superoxide dismutase(SOD),total antioxidant capacity(T-AOC),adiponectin in the two groups increased(P<0.05),malondialdehyde(MDA) decreased(P<0.05),adiponectin level in the observation group was higher than that in the control group(P<0.05) and MDA level was lower than that in the controlled group(P<0.05).The volume of visceral fat, subcutaneous fat volume and visceral fat volume/subcutaneous fat volume decreased between the two groups after treatment(P<0.05).The volume of visceral fat, subcutaneous fat volume and visceral fat volume/subcutaneous fat volume in the observation group were lower than those in the controlled group(P<0.05).Conclusion: Using Huanglian Qingre Tongluo Recipe combined with Lilaru Peptide in the treatment of obese type 2 diabetes can reduce abdominal fat volume, improve the body’s antioxidant ability, and effectively control blood sugar and body mass index.

关 键 词：黄连清热通络方 利拉鲁肽 肥胖 2型糖尿病 氧化应激 腹部脂肪 

分 类 号：R587.1[医药卫生—内分泌]