Constructing the rodent stereotaxic brain atlas:a survey  

作　　者：Zhao Feng Anan Li Hui Gong Qingming Luo 

机构地区：[1]Britton Chance Center for Biomedical Photonics,Wuhan National Laboratory for Optoelectronics,MOE Key Laboratory for Biomedical Photonics,Huazhong University of Science and Technology,Wuhan 430074,China [2]HUST-Suzhou Institute for Brainsmatics,Suzhou 215123,China [3]School of Biomedical Engineering,Hainan University,Haikou 570228,China

出　　处：《Science China(Life Sciences)》2022年第1期93-106,共14页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(61721092,81827901,61890950,and 61890951)。

摘　　要：The stereotaxic brain atlas is a fundamental reference tool commonly used in the field of neuroscience.Here we provide a brief history of brain atlas development and clarify three key conceptual elements of stereotaxic brain atlasing:brain image,atlas,and stereotaxis.We also refine four technical indices for evaluating the construction of atlases:the quality of staining and labeling,the granularity of delineation,spatial resolution,and the precision of spatial location and orientation.Additionally,we discuss state-of-the-art technologies and their trends in the fields of image acquisition,stereotaxic coordinate construction,image processing,anatomical structure recognition,and publishing:the procedures of brain atlas illustration.We believe that the use of single-cell resolution and micron-level location precision will become a future trend in the study of the stereotaxic brain atlas,which will greatly benefit the development of neuroscience.

关 键 词：brain atlas STEREOTAXIC CYTOARCHITECTURE brainsmatics 

分 类 号：Q189[生物学—神经生物学]