生活方式指导联合优泌乐25、阿卡波糖治疗老年2型糖尿病的临床观察  

Clinical Observation on the Treatment of Elderly Type 2 Diabetes by Lifestyle Guidance Combined with Youpile 25 and Acarbose

作　　者：孙雪萍 SUN Xueping(Department of Endocrinology,Dandong Hospital of Traditional Chinese Medicine,Dandong 118000,China)

机构地区：[1]丹东市中医院内分泌科,辽宁丹东118000

出　　处：《中国医药指南》2022年第4期90-92,共3页Guide of China Medicine

摘　　要：目的分析2型糖尿病特点,探讨生活方式指导联合优泌乐25、阿卡波糖治疗老年2型糖尿病的临床效果。方法选择2018年6月至2019年6月收治的128例老年2型糖尿病患者,以随机数字表法分为两组(对照组与研究组)各64例。对照组采用阿卡波糖治疗,研究组采用优泌乐25联合阿卡波糖治疗,同时两组均予以生活方式指导。分别在治疗前后检测空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、单核细胞趋化蛋白-1(MCP-1)、纤溶酶原激活物抑制物-1(PAI-1)等水平,分析患者低血糖发生率。结果治疗后,研究组老年2型糖尿病患者的FPG为(6.73±0.72)mmol/L、2 hPG为(8.93±0.51)mmol/L、HbA1c为(7.03±0.71)%,对照组分别为(8.72±0.93)mmol/L、(11.52±0.72)mmol/L、(9.73±0.66)%,组间比较有统计学意义(P<0.05)。治疗后,研究组老年2型糖尿病患者的hs-CRP为(6.73±0.72)μg/mL、TNF-α为(5.72±2.41)pg/mL、MCP-1为(214.27±33.52)pg/mL、PAI-1为(1.73±0.62)μg/mL,对照组分别为(7.34±2.40)μg/mL、(13.26±3.11)pg/mL、(337.52±37.21)pg/mL、(3.51±0.58)μg/mL,组间比较有统计学意义(P<0.05)。另外,研究组患者低血糖发生率明显低于对照组,组间比较有统计学意义(P<0.05)。结论老年2型糖尿病患者采用生活方式指导联合优泌乐25、阿卡波糖治疗,可有效控制血糖,并能减轻机体炎性反应,减少患者低血糖发生风险,促进患者预后。Objective To analyze the characteristics of type 2 diabetes and to explore the clinical effect of lifestyle guidance combined with Youpile 25 and acarbose in the treatment of type 2 diabetes in the elderly.Methods A total of 128 elderly patients with type 2 diabetes who were admitted from June 2018 to June 2019 were selected and divided into two groups(control group and study group)with 64 cases in each group by random number table.The control group was treated with acarbose,and the study group was treated with Youpile 25 combined with acarbose.At the same time,both groups were given lifestyle guidance.Detect fasting plasma glucose(FPG),2 hours blood glucose after meal(2 hPG),glycosylated hemoglobin(HbA1c),and high sensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),monocyte chemotactic protein-1(MCP-1),plasminogen activator inhibitor-1(PAI-1)and other levels were used to analyze the incidence of hypoglycemia in patients before and after treatment.Results After treatment,the FPG of the elderly type 2 diabetic patients in the study group was(6.73±0.72)mmol/L,2 hPG was(8.93±0.51)mmol/L,HbA1c was(7.03±0.71)%,and the control group was(8.72±0.93)mmol/L,(11.52±0.72)mmol/L,(9.73±0.66)%,the comparison was statistically significant(P<0.05).After treatment,the hs-CRP of the elderly type 2 diabetic patients in the study group was(6.73±0.72)μg/mL,TNF-αwas(5.72±2.41)pg/mL,and MCP-1 was(214.27±33.52)pg/mL,PAI-1 is(1.73±0.62)μg/mL,the control group is(7.34±2.40)μg/mL,(13.26±3.11)pg/mL,(337.52±37.21)pg/mL,(3.51±0.58)μg/mL,the comparison was statistically significant(P<0.05).In addition,the incidence of hypoglycemia in the study group was significantly lower than that in the control group,which was statistically significant(P<0.05).Conclusion The use of lifestyle guidance in elderly patients with type 2 diabetes combined with Youpile 25 and acarbose therapy can effectively control blood sugar,reduce the body's inflammatory response,reduce the risk of hypoglycemia in patients,and promote the pr

关 键 词：生活方式指导 优泌乐25 阿卡波糖 老年 2型糖尿病 低血糖 机体炎性反应 血糖指标水平 

分 类 号：R587.1[医药卫生—内分泌]