枸橼酸氯米芬与来曲唑治疗多囊卵巢综合征不孕的效果研究  

Effect of clomiphene citrate and Letrozole on infertility with polycystic ovary syndrome

作　　者：吕凤珍 Lv Fengzhen(Department of Gynecology,Yulin Hospital of Traditional Chinese Medicine,Yulin 537000,China)

机构地区：[1]玉林市中医医院妇科,广西玉林537000

出　　处：《实用妇科内分泌电子杂志》2021年第12期61-63,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的研究在多囊卵巢综合征不孕治疗中应用枸橼酸氯米芬与来曲唑的效果。方法选取50例多囊卵巢综合征不孕患者,通过抽签法将患者分为对照组与研究组,每组25例。对照组应用枸橼酸氯米芬治疗,研究组应用来曲唑治疗。比较两组患者子宫内膜厚度、卵泡发育状况、内分泌指标以及排卵率、妊娠率、早期流产率。结果研究组优势卵泡数量、卵泡总数量明显多于对照组,子宫内膜厚度厚于对照组,差异有统计学意义(P<0.05);两组卵泡生长时间比较,差异无统计学意义(P>0.05)。研究组雌二醇(E_(2))、血清抗苗勒管激素(AMH)、孕酮(P)水平明显高于对照组,卵泡刺激素(FSH)、促黄体生成素(LH)水平明显低于对照组,差异有统计学意义(P<0.05)。研究组排卵率96.00%、妊娠率60.00%均明显高于对照组的72.00%、28.00%,差异有统计学意义(P<0.05);两组早期流产率比较,差异无统计学意义(P>0.05)。结论多囊卵巢综合征不孕患者治疗期间,相比枸橼酸氯米芬治疗,来曲唑治疗效果更为理想,可有效促进排卵,提升妊娠率。Objective To study the effect of clomiphene citrate and letrozole in infertility treatment of polycystic ovary syndrome.Methods 50 infertile patients with polycystic ovary syndrome were selected and divided into control group and research group by drawing lots,with 25 cases in each group.The control group was treated with clomiphene citrate and the study group was treated with letrozole.Endometrial thickness,follicular development,endocrine indicators,ovulation rate,pregnancy rate and early abortion rate were compared between the two groups.Results The number of dominant follicles and the total number of follicles in the study group were significantly higher than those in the control group,and the endometrial thickness was thicker than that in the control group,with statistical significance(P<0.05).There was no significant difference in follicular growth time between the two groups(P>0.05).The levels of estradiol(E_(2)),serum antimullerian hormone(AMH)and progesterone(P)in the study group were significantly higher than those in the control group,while the levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH)were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Ovulation rate 96.00%and pregnancy rate 60.00%in the study group were significantly higher than those in the control group 72.00%and 28.00%,with statistical significance(P<0.05).There was no significant difference in early abortion rate between the two groups(P>0.05).Conclusion During the treatment of infertility patients with polycystic ovary syndrome,compared with clomiphene citrate treatment,letrozole treatment is more ideal,which can effectively promote ovulation and improve pregnancy rate.

关 键 词：多囊卵巢综合征不孕 枸橼酸氯米芬 来曲唑 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]