N170在阿尔兹海默病中的应用现状  

Application status of N170 in Alzheimer’s disease

作　　者：付雨桐 姚黎清[1] 欧吉兵[1] 何影[1] 李霖荣 王安娟 孔旭 陆芳[1] 樊红[1] FU Yutong;YAO Liqing;OU Jibing;HE Ying;LI Linrong;WANG Anjuan;KONG Xu;LU Fang;FAN Hong(Department of Rehabilitation Medicine,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院康复医学部,云南昆明650101

出　　处：《中国医学物理学杂志》2022年第1期95-99,共5页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(81760414);云南省康复临床医学中心脑卒中诊疗技术项目(zx2019-04-02);云南省科技计划项目重大科技专项(2018ZF016);国家重点研发计划(2018YFC20023301)。

摘　　要：阿尔兹海默病(AD)患者存在面部感知障碍,N170可作为面孔刺激过程中大脑认知加工过程的标志物,利用事件相关电位评价AD患者的面孔识别和加工的缺陷是目前研究的热点,也是临床亟需解决的难点之一。本文就面孔识别的认知加工过程和事件相关电位表现特点以及AD患者的异常N170特征进行全面阐述,解析N170在AD患者中的研究现状,发现AD患者面孔识别的神经机制尚未有统一定论。提出未来医务人员应该进一步使用更敏感、统一的范式,揭示面孔识别的内隐神经心理学时间过程,更深层次地探究N170成为AD患者社会功能障碍的诊断、监测治疗进展的生物标志物证据。Patients with Alzheimer’s disease(AD)suffered from impaired face perception.N170 can be taken as a marker in brain cognitive processing during facial stimulation.Therefore,using event-related potential to evaluate the defects in face recognition and processing in AD patients is a hotspot of current research,and is also one of the difficulties to be solved in clinic.Herein the cognitive processing of face recognition and the characteristics of event-related potential as well as the abnormal N170 characteristics of AD patients are comprehensively described,and the research status of N170 in AD patients is analyzed.It is found that the neural mechanism of face recognition in AD patients still remains unclear.In the future,medical staff should use a more sensitive and unified paradigm to reveal the implicit neuropsychological time process of face recognition,and further explore the evidence for N170 as a biomarker in diagnosing the social dysfunctions of AD patients and monitoring the process of treatment.

关 键 词：阿尔兹海默病 N170 事件相关电位 面孔识别 综述 

分 类 号：R318[医药卫生—生物医学工程] R749.16[医药卫生—基础医学]