从癌毒理论探讨解毒类中药在晚期结直肠癌中的应用概述  

Application of Detoxifying Traditional Chinese Medicine in Advanced Colorectal Cancer Based on Theory of Cancer Toxin

作　　者：王曦妤 吴行 石齐 殷晓聆[1] 石坤和[1] 阮倩雨 阎国良[1] 唐宇飞 吕祥[1] 侯风刚[1] WANG Xiyu;WU Xing;SHI Qi;YIN Xiaoling;SHI Kunhe;RUAN Qianyu;YAN Guoliang;TANG Yufei;LYU Xiang;HOU Fenggang(Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai 200071,China;Baoshan Branch,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201999,China)

机构地区：[1]上海中医药大学附属市中医医院,上海200071 [2]上海中医药大学附属曙光医院宝山分院,上海201999

出　　处：《山东中医杂志》2022年第2期224-232,共9页Shandong Journal of Traditional Chinese Medicine

基　　金：上海市进一步加快中医药事业发展三年行动计划资助项目(编号:ZY〔2018—2020〕-FWTX-6008);上海市卫生和计划生育委员会科研基金(编号:2018LP028);上海市卫生和计划生育委员会科研基金(编号:171310)。

摘　　要：解毒类中药运用于晚期结直肠癌的治疗研究广泛。现代中医学者提出“癌毒”理论,认为其是肠癌复发转移的必要致病因子,解毒抗癌是晚期肠癌的重要治法之一。根据《中国药典临床用药须知》可将解毒类中药分为矿物类3味、动物类5味及植物类40味。通过检索各类解毒中药应用于晚期结直肠癌的文献,归纳出矿物、动物与植物类解毒中药对晚期结直肠癌的作用机制,不同给药途径的临床疗效,药物的毒副作用及名家用药配伍经验,为延长晚期结直肠癌患者生存期、改善生存质量提供诊疗思路。参考文献92篇。Detoxifying Chinese medicine has been widely researched and used in the treatment of advanced colorectal cancer.Modern Chinese medicine scholars put forward the theory of“cancer toxin”and hold that it is the necessary pathogenic factor of colorectal cancer recurrence and metastasis,detoxification and anticancer is one of the important treatment methods of advanced colorectal cancer.According to the Clinical Medication Instructions of Chinese Pharmacopoeia,detoxification traditional Chinese medicine can be divided into 3 mineral medicinals,5 animal medicinals and 40 herb medicinals.By retrieving all kinds of detoxification medicinals used in advanced colorectal cancer literature,the mechanism of action of mineral,animal and herb detoxifying traditional Chinese medicine on advanced colorectal cancer,the clinical efficacy of different drug administration routes,the toxic and side effects of drugs and the experience of famous doctors in drug compatibility are summarized to provide diagnosis and treatment ideas for prolonging the survival period and improving the quality of life of patients with advanced colorectal cancer.There are 92 references in this study.

关 键 词：晚期结直肠癌 解毒中药 动物药 植物药 矿物药 癌毒 

分 类 号：R273.535[医药卫生—中西医结合]