RNA酶Rrp44的结构和功能  

Structure and Function of RNase Rrp44

作　　者：刘洪岩[1] 薛晖[1] 张世勇[1] 赵彦华[1] 王明华[1] 边文冀[1] 陈校辉[1] LIU Hong-yan;XUE Hui;ZHANG Shi-yong;ZHAO Yan-hua;WANG Ming-hua;BIAN Wen-ji;CHEN Xiao-hui(Freshwater Fishery Research Institute of Jiangsu Province,Nanjing,Jiangsu 210017,China)

机构地区：[1]江苏省淡水水产研究所,江苏南京210017

出　　处：《水产养殖》2021年第11期8-11,共4页Journal of Aquaculture

基　　金：现代农业产业技术体系专项资金(CARS-46);江苏省农业重大新品种创制项目(PZCZ201741)。

摘　　要：Rrp44是一种保守的RNA酶,是外切酶复合体的催化亚基,催化细胞核和细胞质RNA 3’至5’降解。Rrp44在RNA质量控制、基因的转录后调控、小RNA的形成等方面有着重要作用。目前,许多关于Rrp44在机体水平上功能的研究表明,Rrp44在细胞周期进程和微管组装中具有重要作用;同时,Rrp44也与哺乳动物B细胞抗体多样化有关。现回顾Rrp44的结构和功能,以加深对Rrp44的认识。Rrp44, a conserved RNase, is a catalytic subunit of exosoma, which catalyzes 3’to 5’degradation of nuclear and cytoplasmic RNA. Rrp44 plays an important role in RNA quality control, post transcriptional regulation of genes, and the formation of small RNA.At present, many studies on the function of Rrp44 at the body level have shown that Rrp44 has essential effect in cell cycle progression and microtubule assembly.Meanwhile, Rrp44 is also associated with mammalian B cell antibody diversification. This article reviewed the structure and functionality of Rrp44, in order to know more about Rrp44.

关 键 词：Rrp44 外切酶复合体 RNA稳定 

分 类 号：Q756[生物学—分子生物学]