沙库巴曲缬沙坦对急性心梗大鼠心功能及脂蛋白相关磷脂酶A2表达水平的影响  

The effect of sakubatril valsartan on the cardiac function and the expression of Lp-PLA2 in rats with acute myocardial infarction

作　　者：周广志 刘爱军[2] 张永林[2] 钱文浩[3] Zhou Guangzhi;Liu Aijun;Zhang Yonglin;Qian Wenhao(The First Clinical Medical College,Xuzhou Medical University,Xuzhou Jiangsu 221004,China;Department of Cardiovascular Medicine,Binhai County People’s Hospital,Yancheng Jiangsu 224500,China;Department of Cardiovascular Medicine,Affiliated Hospital of Xuzhou Medical University,Xuzhou Jiangsu 221000,China)

机构地区：[1]徐州医科大学第一临床医学院,江苏徐州221004 [2]滨海县人民医院心血管内科,江苏盐城224500 [3]徐州医科大学附属医院心血管内科,江苏徐州221000

出　　处：《遵义医科大学学报》2021年第6期699-704,共6页Journal of Zunyi Medical University

摘　　要：目的研究沙库巴曲缬沙坦对急性心肌梗死(AMI)大鼠左心功能及脂蛋白相关磷脂酶A2(Lp-PLA2)表达水平的影响。方法把大鼠随机分为3组,Sham组、AMI组和VALS组。分别观察3组大鼠的心功能指标,血浆Lp-PLA2、hs-CRP水平,大鼠体重、左心室重量、左室重量指数,心肌组织病理学变化和心肌梗死面积。结果AMI组LVEDD和LVESD值明显升高,LVEF和LVFS水平降低;VALS组较AMI组得到了明显改善(P<0.05);AMI组Lp-PLA2、hs-CRP水平较Sham组升高(P<0.05);与AMI组相比,VALS组Lp-PLA2、hs-CRP水平明显回降(P<0.05);AMI组大鼠的体重、左心室质量和左室质量指数高于Sham组(P<0.05);VALS组以上指标均回降(P<0.05);与Sham组相比,AMI组心肌梗死面积及心肌梗死面积/左心室面积均升高(P<0.05);与AMI组相比,VALS组心肌梗死面积显著减少,心肌梗死面积/左心室面积的百分比也明显降低(P<0.05)。结论沙库巴曲缬沙坦可改善急性心肌梗死大鼠心功能,抑制血浆中炎性因子Lp-PLA2和hs-CRP的水平,对心肌组织起到保护作用。Objective To study the effects of Sakobactril Valsartan on left heart function and lipoprotein-associated phospholipase A2(Lp-PLA2)expression in rats with acute myocardial infarction(AMI).Methods The rats were randomly divided into Sham group,AMI group and Sakobactril Valsartan(VALS)group.Cardiac function indexes,plasma Lp-PLA2 and high-sensitivity C-reactive protein(hs-CRP)levels,body weight,left ventricular weight,left ventricular mass index,myocardial histopathological changes and myocardial infarction area of rats in three groups were observed.Results LVEDD and LVESD values were significantly increased in AMI group,while LVEF and LVFS levels were decreased.The VALS group was significantly improved compared with AMI group(P<0.05);The levels of Lp-PLA2 and hs-CRP in AMI group were higher than those in Sham group(P<0.05).Compared with AMI group,the levels of Lp-PLA2 and hs-CRP in VALS group decreased significantly(P<0.05);The body weight,left ventricular mass and left ventricular mass index in AMI group were higher than those in Sham group(P<0.05).All the above indexes in VALS group decreased(P<0.05);Compared with Sham group,myocardial infarction area and myocardial infarction area/left ventricular area were increased in AMI group(P<0.05).The infarct size and the percentage of infarct size/left ventricular area in the VALS group were significantly lower than those in the AMI group(P<0.05).Conclusion Sakobactril Valsartan can improve the cardiac function of acute myocardial infarction rats,inhibit the levels of inflammatory factors Lp-PLA2 and hs-CRP in plasma,and protect the myocardial tissue.

关 键 词：沙库巴曲缬沙坦 急性心肌梗死 心功能 LP-PLA2 

分 类 号：R541.4[医药卫生—心血管疾病]