登革热患者外周血中异型淋巴细胞的变化及临床意义  

Changes and clinical significance of abnormal lymphocytes in peripheral b lood of patients with dengue fever

作　　者：罗嫚[1] 余超[1] LUO Man;YU Chao(Department of Clinical Laboratory,Xishuangbanna Dai Autonomous Prefecture People’s Hospital,Xishuangbanna 666100,Yunnan,China)

机构地区：[1]云南省西双版纳傣族自治州人民医院检验科,云南西双版纳666100

出　　处：《当代医药论丛》2022年第2期154-157,共4页

摘　　要：目的:探讨登革热患者外周血中异型淋巴细胞的变化及临床意义。方法:选取2019年6月至2019年12月云南省西双版纳傣族自治州人民医院收治的100例登革热患者及同期在该医院接受健康体检的100例健康人为研究对象。将100例登革热患者作为观察组,将100名健康人作为对照组。对两组受检者均进行外周血涂片检验,对比其白细胞计数、血小板计数及异型淋巴细胞百分比,分析治疗前后观察组患者上述指标的变化情况。结果:治疗前,观察组患者外周血中的白细胞计数、血小板计数均低于对照组受检者,外周血中异型淋巴细胞百分比高于对照组受检者,P<0.05。治疗后第5 d,观察组患者外周血中的白细胞计数、血小板计数均低于治疗后第1 d、第3 d,外周血中异型淋巴细胞百分比高于治疗后第1 d、第3 d,P<0.05。与治疗前相比,治疗后观察组患者外周血中的异型淋巴细胞百分比、异型淋巴细胞的阳性检出率均较低,P<0.05。结论:登革热患者外周血中异型淋巴细胞的含量明显高于健康人。对该病患者进行治疗后,其外周血中异型淋巴细胞的含量可明显降低。临床上可通过检验登革热患者外周血中异型淋巴细胞的含量,早期诊断其病情,评估其治疗效果。Objective:To investigate the changes and clinical significance of abnormal lymphocytes in peripheral blood of dengue patients.Methods:A total of 100 dengue patients admitted to The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture in Yunnan province from June 2019 to December 2019 and 100 healthy people receiving physical examination in the hospital during the same period were selected as the study subjects.A total of 100 dengue patients were selected as the observation group and 100 healthy people as the control group.Peripheral blood smear test was performed on all subjects in the two groups,and the white blood cell count,platelet count and percentage of abnormal lymphocytes were compared to analyze the changes of the above indicators in the observation group before and after treatment.Results:Before treatment,the white blood cell count and platelet count in peripheral blood of observation group were lower than those in control group,and the percentage of abnormal lymphocytes in peripheral blood was higher than that in control group,P<0.05.On the 5th day after treatment,the white blood cell count and platelet count in peripheral blood of observation group were lower than that on the 1st and 3rd day after treatment,and the percentage of abnormal lymphocytes in peripheral blood was higher than that on the 1st and 3rd day after treatment,P<0.05.Compared with before treatment,the percentage of abnormal lymphocytes and positive detection rate of abnormal lymphocytes in peripheral blood of observation group were lower after treatment,P<0.05.Conclusion:The content of abnormal lymphocytes in peripheral blood of patients with dengue fever is significantly higher than that of healthy people.After the treatment of the patients with the disease,the content of peripheral blood lymphocytes can be significantly reduced.In clinic,we can detect the abnormal lymphocyte content in peripheral blood of patients with dengue fever to diagnose the disease early and evaluate the therapeutic effect.

关 键 词：登革热 异型淋巴细胞 白细胞计数 血小板计数 

分 类 号：R44[医药卫生—诊断学]