灯盏乙素在抑制冠脉搭桥术后静脉桥再狭窄中的应用  

The Application of Breviscapine on Graft Restenosis in Coronary Artery Bypass Grafting

作　　者：张浒[1] 彭安睿 钟佳冀 黄波[2] 白鹏[3] ZHANG Hu;PENG Anrui;ZHONG Jiaji;HUANG Bo;BAI Peng(Dept.of Cardiovascular Surgery,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China;Operating Room,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China;Dept.of Neurosurgery,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院心脏大血管外科,云南昆明650032 [2]昆明医科大学第一附属医院麻醉手术科,云南昆明650032 [3]昆明医科大学第一附属医院微创神经外科,云南昆明650032

出　　处：《昆明医科大学学报》2022年第1期59-62,共4页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE467(-029)];云南省教育厅科学研究基金资助项目(2021J0242)。

摘　　要：目的通过临床对照研究,观察灯盏乙素对冠状搭桥术后静脉桥再狭窄的作用。方法根据入选和排除标准纳入冠脉搭桥术后患者64例,随机平均分2组(n=32),对照组患者术后口服常规药物,治疗组除常规药物外,增加灯盏花素片,术后3个月、6个月多层计算机断层血管造影(MSCTA)来检测静脉桥,评估静脉桥再狭窄,2组对比分析。结果3和6个月后,灯盏乙素组静脉桥再狭窄程度低于对照组,差异有统计学意义(P<0.05)。结论口服灯盏乙素有助于减轻冠脉搭桥后静脉桥再狭窄。Objective To explore the protective effect of breviscapine on graft vein grafting in the patients who underwent Coronary Artery Bypass Graft(CABG).Methods According to the inclusion criteria and exclusion criteria,64 patients entered the study and were randomly divided into two groups(n=32).Group A was the control group,in which patients took oral routine drugs including aspirin,clopidogrel and atorvastatin;Group B was the treatment group,in which patients took oral routine drugs+breviscapine.The rate of graft stenosis was examined by Multi-slics Computed Tomography Angiography(MSCTA)3 months and 6 months after CABG.Results The rate of graft stenosis in the treatment group was significantly lower than that in the control group 3 and 6 months after CABG(P<0.05).Conclusion Breviscapine has a protective effect on graft veins in patients who underwent CABG.

关 键 词：冠脉搭桥术 静脉桥 再狭窄 灯盏乙素 抑制 

分 类 号：R332[医药卫生—人体生理学]