氯虫苯甲酰胺衍生物的合成及杀虫活性  

Synthesis and insecticidal activity of derivatives of chlorantraniliprole

作　　者：杜晓华 方佳琪 楼佳明 DU Xiaohua;FANG Jiaqi;LOU Jiaming(Catalytic Hydrogenation Research Center,Zhejiang University of Technology,Hangzhou 310014,China;Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology,Hangzhou 310014,China;Zhejiang Green Pesticide Collaborative Innovation Center,Hangzhou 310014,China)

机构地区：[1]浙江工业大学催化加氢中心,浙江杭州310014 [2]浙江省绿色农药清洁生产技术研究重点实验室,浙江杭州310014 [3]浙江省绿色农药协同创新中心,浙江杭州310014

出　　处：《浙江工业大学学报》2022年第1期44-49,54,共7页Journal of Zhejiang University of Technology

基　　金：国家重点研究和发展计划项目(2016YFD0300708)。

摘　　要：为了开发新的杀虫化合物,以氯虫苯甲酰胺为先导,通过引入氨基酸片段合成了12个新化合物,通过^(1)H NMR,^(13)C NMR和HRMS等手段进行结构表征。室内杀虫活性初步测试结果表明:在500 mg/L测试质量浓度下,多数目标化合物对黏虫(Oriental armyworm)有着较高的杀虫活性,其中化合物b在20,4 mg/L质量浓度下对黏虫分别有90%和80%的杀虫活性,化合物f在20,4 mg/L质量浓度下对黏虫分别有80%和70%的杀虫活性。In order to find and develop new insecticidal compounds,12 compounds were designed and synthesized by introducing amino acids into the lead compound chlorantraniliprole.Their structures were characterized by ^(1)H NMR,^(13)C NMR and HRMS.The bioactivity test results showed that most of the title compounds showed good insecticidal activity against oriental armyworm.Compound b showed 90%and 80%insecticidal activity against armyworm at 20,4 mg/L,respectively,and compound f showed 80%and 70%insecticidal activity against armyworm at 20,4 mg/L,respectively.

关 键 词：氯虫苯甲酰胺衍生物 氨基酸片段 杀虫活性 

分 类 号：O626.321[理学—有机化学]