生物酶与化学催化剂结合在合成手性化合物中的应用  

Application of Biological Enzyme and Chemical Catalyst in Synthesis of Chiral Compounds

作　　者：张媛媛 温叶倩 ZHANG Yuanyuan;WEN Yeqian(School of Chemical Engineering and Technology,Hebei University of Technology,Tianjin 300130,China)

机构地区：[1]河北工业大学化工学院,天津300130

出　　处：《材料导报》2022年第2期190-199,共10页Materials Reports

基　　金：国家自然科学基金(21606069);河北省自然科学基金(B2017202187)。

摘　　要：手性化合物在医药、材料等领域展现了其独特的优势。为了满足各界对光学纯手性化合物的需求,各种合成方法得到了较快的发展,其中化学酶和多酶参与的催化循环因其对环境友好、选择性高、条件温和等优点而受到越来越多的重视。本文综述了合成光学纯化合物的循环网络的最新进展并对其今后的发展方向进行了展望,其中包括三种方法。(1)动态动力学拆分法(DKR):大部分研究工作集中在对仲醇的拆分,特别是芳香类仲醇,而发展适用于胺化合物的DKR的催化体系仍然是科研工作者们的重要任务。(2)少量对映体回收方法(MER):手性合成领域的一种新的反应模式,已经成功应用于手性氰醇酯类化合物、环状手性胺化合物的合成。(3)环消旋法(CyD):是合成手性胺的一种具有吸引力的方法。Chiral compounds have already presented unique advantages in many fields,such as medicine field,material field,etc.In face of the increasingly requirements for optical pure compounds,many methods have been developed.Among them,catalytic cycle involving chemical enzyme and multienzyme attracted more and more attention due to the advantages of environment-friendly process,high selectivity,and mild conditions.In this paper,the latest development of the cyclic network for the synthesis of optically pure compounds is reviewed,including three methods.(1)Dynamic kinetic resolution(DKR):most of the research work focused on the resolution of secondary alcohols,especially aromatic secondary alcohols.However,chiral resolution of anines is still challenging problems.(2)Minor enantiomer recycling(MER):it is a new reaction mode in the field of chiral synthesis and has been successfully applied to the synthesis of chiral cyanohydrin esters and cyclic chiral amines.(3)Cyclic deracemisation(CyD):this is an attractive method for the synthesis of chiral amines.

关 键 词：手性化合物 酶 外消旋化 循环 

分 类 号：O622.3[理学—有机化学] O622.6[理学—化学]