母孕期及新生儿早期钙剂补充对婴儿发育质量和肠道菌群的影响  

Effects of calcium intake during pregnancy and early neonatal period on physical development and intestinal flora of infants

作　　者：费桃勤 霍婧 潘春波 FEI Tao-qin;HUO Jing;PAN Chun-bo(Department of Obstetrics and Gynecology,Liyatig Branch of Jiangsu Provincial People's Hospital,Liyang 213300,China)

机构地区：[1]江苏省人民医院溧阳分院妇产科,江苏溧阳213300

出　　处：《哈尔滨医科大学学报》2021年第5期500-504,共5页Journal of Harbin Medical University

基　　金：江苏省自然科学基金资助项目(BK20170610)。

摘　　要：目的研究母孕期及新生儿早期钙摄入对婴儿体格发育和肠道菌群的影响。方法选择2018年1月~2020年1月在本院生产的156例孕产妇作为研究对象,使用随机数表法将所有孕妇分为A、B、C、D 4组,每组39例。A组孕妇在孕期补充钙剂,新生儿早期补充钙剂和维生素D滴剂;B组孕妇在孕期补充钙剂,在新生儿早期补充维生素D滴剂;C组新生儿早期补充钙剂和维生素D滴剂;D组新生儿早期补充维生素D滴剂。记录4组婴儿出生体格发育情况(出生体重、出生身长、38周双顶径);记录不同生长时期身体质量指数(BMI),包括出生BMI、6月龄BMI、6个月增量;统计4组出生体重分布情况,最后检测婴儿肠道菌群情况,检测拟杆菌门、变形菌门、乳杆菌属和双歧杆菌属的含量。结果4组出生体重分别为(3467.25±326.37)g、(3479.56±485.84)g、(3259.74±472.13)g、(3237.56±449.71)g,A、B组出生体重无明显差异(P>0.05),C、D组出生体重无明显差异(P>0.05),但A、B组出生体重高于C、D组,差异有统计学意义(P<0.05);4组出生身长分别为(50.17±2.08)cm、(50.32±1.93)cm、(48.32±1.44)cm、(48.25±1.37)cm,A、B组出生身长无明显差异(P>0.05),C、D组出生身长无明显差异(P>0.05),但A、B组出生身长高于C、D组,差异有统计学意义(P<0.05);4组6月龄BMI分别为(18.26±0.58)kg/m^(2)、(17.15±0.82)kg/m^(2)、(18.47±0.49)kg/m^(2)、(16.12±1.17)kg/m^(2),6个月增量分别为(5.24±0.39)kg/m^(2)、(4.68±0.35)kg/m^(2)、(5.38±0.42)kg/m^(2)、(4.05±0.36)kg/m^(2),A、C组6月龄BMI和6个月增量无明显差异(P>0.05),并且A、C组6月龄BMI和6个月增量高于B组,B组6月龄BMI和6个月增量高于D组,差异有统计学意义(P<0.05);A、B组无低出生体重儿,分别有3、4例巨大儿,C、D组无巨大儿,分别有7、5例低出生体重儿,A、B组巨大儿发生率高于C、D组,C、D组低出生体重儿发生率高于A、B组,差异均有统计学意义(P<0.05);4组乳杆菌属含量分别为20.Objective To study the effects of calcium intake during pregnancy and early neonatal period on physical development and intestinal flora of infants.Methods A total of 156 cases of pregnant women in our hospital from January 2018 to January 2020 were selected as the research objects,and all pregnant women were randomly divided into group A,group B,group C and group D,with 39 cases in each group.The pregnant women in group A were given calcium supplement during pregnancy,and the newborns were given calcium supplement and vitamin D drop in the early stage;The pregnant women in group B were given calcium supplement during pregnancy,and the newborns were given vitamin D drop in the early stage;The newborns in group C were given calcium supplement and vitamin D drop in the early stage;The newborns in group D were given vitamin D drop in the early stage.The physical development at birth(birth weight,birth length,38 weeks double apical diameter)of the 4 groups were recorded.Body mass index(BMI)was recorded at different growth periods,including BMI at birth,BMI at 6 months,and 6-month increment.The distribution of birth weight of the four groups was analyzed.Finally,the intestinal flora of infants was detected,and the contents of Bacteroidetes,Proteobacteria,Lactobacillus and Bifidobacteria were detected.Results The birth weight of 4 groups were(3467.25±326.37)g,(3479.56±485.84)g,(3259.74±472.13)g,and(3237.56±449.71)g,respectively.There was no significant difference in birth weight between group A and B(P>0.05).There was no significant difference in birth weight between group C and D(P>0.05),but the birth weight of group A and B was higher than that of group C and D,and the difference was statistically significant(P<0.05).The birth length of the 4 groups were(50.17±2.08)cm,(50.32±1.93)cm,(48.32±1.44)cm,and(48.25±1.37)cm,respectively.There was no significant difference in the birth length of group A and B(P>0.05),and there was no significant difference in the birth length of group C and D(P>0.05).However,the birth

关 键 词：婴儿 补钙 出生体重 出生身长 身体质量指数 肠道菌群 

分 类 号：R714.7[医药卫生—妇产科学]