中性粒细胞与淋巴细胞比值预测老年不稳定性心绞痛患者介入治疗远期预后  

Value of neutrophil to lymphocyte ratio for predicting long-term outcome in elderly UAP patients after PCI

作　　者：张莹莹[1] 郭绪昆[1] 郑君毅[1] 刘婷 张莹 马静 刘寅[1] Zhang Yingying;Guo Xukun;Zheng Junyi;Liu Ting;Zhang Ying;Ma Jin;Liu Yin(Department of Cardiology,Tianjin Chest Hospital,Tianjin 300222,China)

机构地区：[1]天津市胸科医院心内科,300222 [2]天津市心血管病研究所分子生物学实验室

出　　处：《中华老年心脑血管病杂志》2022年第1期22-25,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：天津市科技计划项目(16ZXMJSY00150);天津市胸科医院院级基金项目(2018XKZ01)。

摘　　要：目的探讨中性粒细胞/淋巴细胞比值(NLR)与接受PCI的老年不稳定性心绞痛(UAP)患者远期预后的关系。方法连续纳入天津市胸科医院成功接受PCI的老年UAP患者514例,根据ROC曲线分析NLR预测PCI后2年主要不良心血管事件(MACE)的最佳临界值4.86,将患者分为高NLR(NLR≥4.86)组81例和低NLR(NLR<4.86)组433例,采用Cox风险比例模型分析。结果与低NLR组比较,高NLR组血小板/淋巴细胞比值升高(226.0±86.7 vs 137.8±51.3,P=0.000),MACE发生率升高(44.4%vs 8.1%,P<0.01)。Cox分析显示,NLR和年龄是MACE发生的独立预测因子(HR=1.434,95%CI:1.282~1.604,P<0.01;HR=1.040,95%CI:1.010~1.071,P<0.01)。结论NLR增高和高龄是老年UAP患者PCI后远期MACE增加的独立危险因素。Objective To study the relationship of neutrophil to lymphocyte ratio(NLR)with the long-term outcome in elderly UAP patients after PCI.Methods Five hundred and fourteen elder-ly UAP patients who underwent successful PCI in our hospital were divided into high NLR group(n=81)and low NLR group(n=433)according to the optimal cut-off value(4.86)of NLR for predicting the incidence of MACE after 2 years of PCI as was shown in ROC curve analysis.By Cox propotional harzards model analysis.Results The PLR was significantly higher while the in-cidence of MACE was significantly lower in high NLR group than in low NLR group(226.0±86.7 vs 137.8±51.3,44.4%vs 8.1%,P<0.01).Cox propotional harzards model analysis showed that NLR and age were independent risk factors for the incidence of MACE in elderly UAP patients(HR=1.434,95%CI:1.282-1.604,P<0.01;HR=1.040,95%CI:1.010-1.071,P<0.01).Conclusion Elevated NLR and advanced age are the independent risk factors for long-term outcome and incidence of MACE in elderly UAP patients after PCI.

关 键 词：中性白细胞 淋巴细胞 心绞痛 不稳定型 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]