氯解磷定联合早期血液灌流救治有机磷农药中毒的疗效观察  

Observation on the clinical efficacy of pralidoxime chloride combined with early hemoperfusion in the treatment of organophosphorus pesticide poisoning

作　　者：魏萍萍 李丽丽 WEI Ping-ping;LI Li-li(Fukuang General Hospital of Liaoning Health Industry Group,Fushun 113000,China)

机构地区：[1]辽宁省健康产业集团抚矿总医院,113000

出　　处：《中国现代药物应用》2021年第24期100-102,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨氯解磷定联合早期血液灌流救治有机磷农药中毒的临床疗效。方法选择78例有机磷农药中毒患者作为研究对象,根据治疗方法不同分为对照组(32例)与观察组(46例)。对照组给予氯解磷定注射液治疗,观察组在对照组基础上早期应用血流灌流治疗。比较两组患者抢救成功率、各项指标恢复时间、治疗前后胆碱酯酶水平。结果观察组抢救成功率93.5%明显高于对照组的78.1%,差异具有统计学意义(P<0.05)。观察组自主呼吸恢复时间、意识恢复时间及胆碱酯酶活力恢复时间分别为(8.41±2.71)、(9.33±1.45)、(3.09±0.11)h,均明显短于对照组的(12.93±3.12)、(13.05±1.59)、(5.21±0.15)h,差异具有统计学意义(P<0.05)。治疗后,观察组患者胆碱酯酶(44.03±3.76)U/L明显高于对照组的(35.71±2.71)U/L,差异具有统计学意义(P<0.05)。结论氯解磷定联合早期血液灌流应用于急诊科有机磷农药中毒的急救中,可明显提升救治成功率,提高患者血清胆碱酯酶水平,降低并发症发生率,建议临床广泛应用。Objective To discuss the clinical efficacy of pralidoxime chloride combined with early hemoperfusion in the treatment of organophosphorus pesticide poisoning.Methods A total of 78 patients with organophosphorus pesticide poisoning were taken as the research subjects,and were divided into the control group(32 cases)and the observation group(46 cases)according to different treatment methods.The control group was treated with pralidoxime chloride injection,and the observation group was treated with early hemoperfusion on the basis of the control group.The success rate of treatment,recovery time of various indicators,and cholinesterase levels before and after treatment were compared between the two groups.Results The success rate of treatment 93.5%of the observation group was significantly higher than 78.1%of the control group,and the difference was statistically significant(P<0.05).The recovery time of spontaneous breathing,consciousness and cholinesterase activity of the observation group were(8.41±2.71),(9.33±1.45),(3.09±0.11)h,respectively,which were significantly shorter than(12.93±3.12),(13.05±1.59),(5.21±0.15)h of the control group,and the difference was statistically significant(P<0.05).After treatment,the cholinesterase(44.03±3.76)U/L of the observation group was significantly higher than(35.71±2.71)U/L of the control group,and the difference was statistically significant(P<0.05).Conclusion Pralidoxime chloride in combination with early hemoperfusion in emergency department of for organophosphorus pesticide poisoning can significantly improve the success rate of treatment,increase the level of serum cholinesterase and reduce the complication rates.It is suggested to be widely used in clinical practice.

关 键 词：氯解磷定 血液灌流 有机磷农药中毒 疗效观察 

分 类 号：R595.4[医药卫生—内科学]