常规抗心衰药物联合β受体阻滞剂对心力衰竭的治疗效果分析  

Analysis of the therapeutic effect of conventional anti-heart failure drugs combined withβ-blockers on heart failure

作　　者：辛星 XIN Xing(Gaizhou Central Hospital,Gaizhou 115200,China)

机构地区：[1]辽宁省盖州市中心医院,115200

出　　处：《中国现代药物应用》2021年第24期150-152,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析常规抗心力衰竭(心衰)药物联合β受体阻滞剂对心衰的治疗效果。方法100例心衰患者,随机分为对照组及观察组,每组50例。对照组患者给予常规抗心衰药物治疗,观察组在对照组基础上给予β受体阻滞剂治疗。比较两组患者治疗前后氨基末端脑钠肽前体、心输出量、超敏C反应蛋白、纽约心脏病协会(NYHA)分级、左心室射血分数及疗效、不良反应发生情况。结果治疗后,两组氨基末端脑钠肽前体、超敏C反应蛋白、NYHA分级均较本组治疗前降低,左心室射血分数、心输出量均较本组治疗前升高,且观察组氨基末端脑钠肽前体(223.62±10.12)pg/ml、超敏C反应蛋白(6.65±0.24)mg/L、NYHA分级(1.33±0.21)级低于对照组的(343.52±12.56)pg/ml、(8.74±0.42)mg/L、(2.33±0.22)级,左心室射血分数(58.41±4.42)%、心输出量(5.23±0.24)L/min高于对照组的(53.41±4.25)%、(4.33±0.18)L/min,差异有统计学意义(P<0.05)。观察组总有效率96.00%高于对照组的80.00%,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论常规抗心衰药物配合β受体阻滞剂对心衰有更好的疗效,可提高心输出量,纠正心衰,改善心功能,安全性高,值得推广。Objective To analyze the therapeutic effect of conventional anti-heart failure drugs combined withβ-blockers on heart failure.Methods A total of 100 patients with heart failure were randomly divided into control group and observation group,with 50 cases in each group.Patients in the control group were treated with conventional anti-heart failure drugs,and the observation group was treated withβ-blockers on the basis of the control group.Both groups were compared in terms of N-terminal pro-brain natriuretic peptide,cardiac output,high-sensitivity C-reactive protein,New York Heart Association(NYHA)grading and left ventricular ejection fraction before and after treatment,efficacy,and occurrence of adverse reactions.Results After treatment,the N-terminal pro-brain natriuretic peptide,high-sensitivity C-reactive protein,and NYHA grading of the two groups were lower than those of this group before treatment,and the left ventricular ejection fraction and cardiac output were all higher than those of this group before treatment;the N-terminal pro-brain natriuretic peptide(223.62±10.12)pg/ml,high-sensitivity C-reactive protein(6.65±0.24)mg/L,and NYHA grading(1.33±0.21)grades of the observation group were lower than(343.52±12.56)pg/ml,(8.74±0.42)mg/L,and(2.33±0.22)grades of the control group,and the left ventricular ejection fraction(58.41±4.42)%and cardiac output(5.23±0.24)L/min were higher than(53.41±4.25)%and(4.33±0.18)L/min of the control group;all the differences were statistically significant(P<0.05).The total effective rate 96.00%in the observation group was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Conventional anti-heart failure drugs combined withβ-blockers is more effective in the treatment of heart failure,which can increase cardiac output,correct heart failure and improve cardiac function,which is safe and worth popul

关 键 词：抗心力衰竭药物 Β受体阻滞剂 心力衰竭 疗效 不良反应 

分 类 号：R541.6[医药卫生—心血管疾病]