IL-34与冠心病合并糖尿病  

IL-34 and coronary heart disease complicated with diabetes mellitus

作　　者：刘慧卿 金凤表[2] 李青联 高宇[2] 刘晓腾 侯瑞田[1] LIU Huiqing;JIN Fengbiao;LI Qinglian;GAO Yu;LIU Xiaoteng;HOU Ruitian(Department of Cardiac Electrophysiology,Hospital Affiliated to Chengde Medical University,Chengde Hebei 067000;Department of Endocrinology,Hospital Affiliated to Chengde Medical University,Chengde Hebei 067000,China)

机构地区：[1]承德医学院附属医院心脏电生理科,河北承德067000 [2]承德医学院附属医院内分泌科,河北承德067000

出　　处：《中南大学学报（医学版）》2021年第12期1409-1414,共6页Journal of Central South University ：Medical Science

摘　　要：冠心病和糖尿病与慢性低度炎症密切相关。白细胞介素-34(interleukin-34,IL-34)是近年来发现的一种促炎因子,主要通过与集落刺激因子-1受体(colony stimulating factor-1 receptor,CSF-1R)结合,参与单核巨噬细胞系统的病理生理过程,与机体炎症和自身免疫性疾病密切相关。IL-34在冠心病、糖尿病患者体内高表达,它通过多途径发挥促炎作用,诱发动脉粥样硬化和胰岛素抵抗,最终导致冠心病、2型糖尿病及其共病的发生和发展。Coronary heart disease and diabetes mellitus are closely related to chronic low-grade inflammation.Interleukin-34(IL-34)is a new member of the interleukin family discovered in recent years.It is involved in the pathophysiological process of mononuclear phagocyte system mainly via binding to colony stimulating factor-1 receptor,and it is closely related to inflammatory and autoimmune diseases.IL-34 is highly expressed in patients with coronary heart disease or diabetes mellitus.IL-34 induces atherosclerosis and insulin resistance through multiple pro-inflammatory actions,ultimately leading to the occurrence and development of coronary heart disease,type 2 diabetes,and their comorbidities.

关 键 词：白细胞介素-34 炎症因子 冠心病 糖尿病 单核巨噬细胞系统 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]