丝素蛋白再生医学材料对细胞功能调控的研究进展  

Silk fibroin-based biomedical materials for cell regulation

作　　者：赵瑞波[1,2] 谢番 罗丹丹[1,2] 孔祥东[1,2] ZHAO Ruibo;XIE Fan;LUO Dandan;KONG Xiangdong(Institute of Smart Biomaterials,School of Materials Science and Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,China;Zhejiang-Mauritius Joint Research Center forBiomaterials and Tissue Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,China)

机构地区：[1]浙江理工大学材料科学与工程学院智能生物材料研究所,杭州310018 [2]浙江理工大学浙江-毛里求斯(浙理)生物医用材料与组织工程联合研究中心,杭州310018

出　　处：《丝绸》2022年第1期10-19,共10页Journal of Silk

基　　金：国家自然科学基金项目(51902289);浙江省自然科学基金项目(LQ19E020010);浙江省教育厅研究项目(Y201840323)。

摘　　要：丝素蛋白是重要的天然生物高分子材料,具有出色的机械性能、生物相容性、生物降解性,易于化学修饰等特性,成为再生医学研究中重要的生物材料。近年来,基于丝素蛋白的再生医学材料在骨、皮肤、神经、胰岛等组织修复和再生医学中被广泛应用研究,丝素蛋白材料对细胞功能调控作用逐渐被阐明并成为其指导设计和构建医用丝素蛋白材料结构的重要参考,加速了丝素蛋白材料在临床医学上的应用。本文在对丝素蛋白性质与再生医学关系进行综述分析的基础上,总结丝素蛋白基生物材料在骨、皮肤、神经、胰岛等再生医学领域中对细胞及关联干细胞的功能调控作用,为丝素蛋白材料的生物医学设计和应用提供新的思路。Silk fibroin is an important natural biopolymer material with excellent mechanical properties,biocompatibility,biodegradability,and easy chemical modification of functional groups.It has received extensive attention in biomedical materials and regenerative medicine research.In recent years,silk fibroin-based regenerative medicine biomaterials have shown good application potential in repair and regenerative medicine concerning tissues such as bone,skin,nerves and pancreatic islets.The interactions between these materials and cells are gradually elucidated,which further provides positive feedback to the silk biomedical materials design and preparation,significantly accelerating the clinical translation of silk fibroin-based biomedical materials.Currently,silk fibroin materials have been manufactured into injectable solution,fiber material,film material,hydrogel material and scaffold material that can mimic the functions of extracellular matrix in the regulation of cell adhesion,proliferation and differentiation.Generally,the biomedical materials in tissue repair and regenerative medicine have several characterizations,such as biocompatibility,low host immune response and good permeability,which could support or enhance cellular life activities to promote tissue repair and regeneration.As an important natural material,silk fibroin has displayed excellent biocompatibility,biodegradability,low immunogenicity,mechanical properties and easy chemical modification of functional groups,presenting high potential in cell regulation for regenerative medicine.The adjustable mechanical strength is another important feature of silk fibroin,which could make its rigidity match thatof cells,revealing an important role in cell division and functional differentiation.In the recent decade,the regulation of silk fibroin material on cell function has been gradually clarified and has become the important cue for design and construction of silk fibroin biomaterials,which accelerates the clinical medicine application of silk fibroin,showin

关 键 词：丝素蛋白 骨细胞 皮肤细胞 神经细胞 胰岛细胞 再生医学 

分 类 号：TS102.1[轻工技术与工程—纺织工程] Q813[轻工技术与工程—纺织科学与工程]