血清MMP-9联合IRS-2蛋白检测对PCOS诊断价值研究  

Study on diagnostic value of serum MMP-9 combined with IRS-2 protein detection for PCOS

作　　者：杜晓琴[1] 王亮[1] 张利容 陈丽娟 马瑛[1] 田茂莹 DU Xiaoqin;WANG Liang;ZHANG Lirong;CHEN Lijuan;MA Ying;TIAN Maoying(Department of Obstetrics and Gynecology,Mianyang Central Hospital,Mianyang,Sichuan 621000,China)

机构地区：[1]绵阳市中心医院妇产科,四川绵阳621000

出　　处：《国际检验医学杂志》2022年第2期213-216,共4页International Journal of Laboratory Medicine

摘　　要：目的研究血清基质金属蛋白酶9(MMP-9)联合胰岛素受体底物-2(IRS-2)蛋白检测对多囊卵巢综合征(PCOS)的诊断价值。方法该研究采取回顾性研究,以该院2017年1月至2019年1月诊断的120例PCOS患者作为观察组,另选取同期体检健康的志愿者100例作为对照组,比较两组性激素、MMP-9、IRS-2蛋白水平之间的差异,分析血清MMP-9联合IRS-2蛋白检测对PCOS的诊断价值。结果两组雌二醇(E2)、孕酮(P)、催乳素(PRL)、卵泡刺激素(FSH)水平比较,差异均无统计学意义(P>0.05),观察组睾酮(T)、促黄体生成素(LH)、MMP-9水平均明显高于对照组(P<0.05),IRS-2蛋白水平明显低于对照组(P<0.05);MMP-9与T、LH均呈正相关(r=0.441、0.526,P<0.05),IRS-2蛋白水平与T、LH均呈负相关(r=-0.452、-0.521,P<0.05),MMP-9、IRS-2蛋白联合检测对PCOS的诊断特异度明显高于单项检测。结论血清MMP-9联合IRS-2蛋白检测对PCOS的诊断特异度较高,建议临床可推广使用。Objective To study the diagnostic value of serum matrix metallopeptidase 9(MMP-9)combined with insulin receptor substrate-2(IRS-2)protein in polycystic ovarian syndrome(PCOS).Methods This study was a retrospective study,a total of 120 cases of PCOS diagnosed in the hospital from January 2017 to January 2019 were selected as the observation group,and 100 healthy volunteers who underwent physical examination in the same period were selected as the control group.The differences of sex hormone,MMP-9 and IRS-2 protein levels between the two groups were compared,and the diagnostic value of serum MMP-9 combined with IRS-2 protein detection for PCOS was analyzed.Results There was no significant difference in Estradiol(E2),progesterone(P),prolactin(PRL),follicle stimulating hormone(FSH)levels between the two groups(P>0.05).Testosterone(T),luteinizing hormone(LH)and MMP-9 levels in the observation group were significantly higher than those in the control group(P<0.05),while IRS-2 protein level was significantly lower than that in the control group(P<0.05).There was a positive correlation between MMP-9 and T and LH(r=0.441,0.526,P<0.05),and a negative correlation between IRS-2 protein level and T and LH levels(r=-0.452,-0.521,P<0.05).The diagnostic specificity of combined detection of MMP-9 and IRS-2 protein levels for PCOS was significantly higher than that of single detection.Conclusion The specificity of serum MMP-9 combined with IRS-2 protein detection in the diagnosis of PCOS is high,so it is recommended to be popularized in clinic.

关 键 词：基质金属蛋白酶9 胰岛素受体底物-2 多囊卵巢综合征 

分 类 号：R271.1[医药卫生—中医妇科学]