血清CTRP9、TNFR1、FGF23与2型糖尿病患者下肢动脉血管病变的相关性研究  

A Study on the Correlation Between Serum CTRP9,TNFR1,FGF23 and Lower Extremity Arterial Disease in Type 2 Diabetic Mellitus Patients

作　　者：潘纯 张光明[1] 弓慧杰[1] PAN Chun;ZHANG Guangming;GONG Huijie(Department of Endocrinology,Chengdu Xindu District People’s Hospital,Chengdu 610500, China)

机构地区：[1]成都市新都区人民医院内分泌科,四川成都610500

出　　处：《标记免疫分析与临床》2021年第12期2074-2077,2146,共5页Labeled Immunoassays and Clinical Medicine

基　　金：四川省卫生厅资助项目(编号:0902105)。

摘　　要：目的探讨2型糖尿病(T2DM)患者血清C1q/肿瘤坏死因子相关蛋白9(CTRP9)、肿瘤坏死因子受体1(TNFR1)、成纤维细胞生长因子23(FGF23)表达水平,分析其与患者下肢动脉血管病变(LEAD)的关系。方法选取2018年1月至2020年1月在我院接收治疗的T2DM患者142例(病例组),根据踝臂指数(ABI),将其分为单纯T2DM组(ABI>0.90,n=95)和合并LEAD组(ABI≤0.90,n=47)。另选取我院体检健康人群100例(观察组)。采用酶联免疫吸附法检测血清CTRP9、TNFR1、FGF23表达水平。应用Pearson相关性分析血清CTRP9、TNFR1、FGF23水平与LEAD的相关性。绘制ROC曲线,分析血清CTRP9、TNFR1、FGF23对T2DM患者LEAD发生的预测价值。结果病例组血清CTRP9、TNFR1、FGF23水平与对照组相比,差异有统计学意义(P<0.05)。LEAD组血清CTRP9水平低于单纯T2DM组,血清TNFR1、FGF23水平高于单纯T2DM组,差异均有统计学意义(P<0.05)。Pearson相关性分析结果显示,血清CTRP9与ABI呈正相关,血清TNFR1、FGF23与ABI呈负相关(均P<0.05)。多因素Logistic回归分析结果显示,血清CTRP9降低,血清TNFR1、FGF23升高是T2DM患者LEAD发生的重要危险因素(P<0.05)。血清CTRP9、TNFR1、FGF23联合检测预测T2DM患者LEAD发生的AUC为0.902,灵敏度和特异性分别为0.731、0.886。结论T2DM患者血清CTRP9水平降低,血清TNFR1、FGF23水平升高,血清CTRP9、TNFR1、FGF23水平变化与患者LEAD的发生密切相关,也是判断T2DM患者LEAD发生的重要生物学指标。Objective To investigate the serum C1q/tumor necrosis factor-related protein 9(CTRP9),tumor necrosis factor receptor 1(TNFR1),and fibroblast growth factor 23(FGF23)expression levels in patients with type 2 diabetes mellitus(T2DM).To analyze their relationships with patients with lower extremity arterial disease(LEAD).Methods 142 T2DM patients(case group)who were treated in our hospital from January,2018 to January,2020 were selected for the study.According to the ankle-brachial index(ABI),these patients were divided into a pure T2DM group(ABI>0.90,n=95)and a combined LEAD group(ABI≤0.90,n=47).Another 100 healthy people in our hospital were selected from physical examination(observation group).Enzyme-linked immunosorbent assay was conducted to detect the expression levels of serum CTRP9,TNFR1,and FGF23.Pearson correlation was applied to analyze the correlation between serum CTRP9,TNFR1,FGF23 levels and LEAD.ROC curve was drawn to evaluate the predictive value of serum CTRP9,TNFR1 and FGF23 on the occurrence of LEAD in T2DM patients.Results Serum levels of CTRP9,TNFR1 and FGF23 in the case group were significantly different from those in the control group(P<0.05).The level of serum CTRP9 in the LEAD group was lower than that of T2DM alone,while the levels of serum TNFR1 and FGF23 were higher than those of T2DM alone(P<0.05).Pearson correlation analysis results showed that serum CTRP9 was positively correlated with ABI,while serum TNFR1 and FGF23 were negatively correlated with ABI(all P<0.05).Multivariate logistic regression analysis showed that decreased serum CTRP9 and increased serum TNFR1 and FGF23 were important risk factors for LEAD in T2DM patients(P<0.05).The combined detection of serum CTRP9,TNFR1,and FGF23 predicting the occurrence of LEAD in T2DM patients had AUC of 0.902,with sensitivity and specificity of 0.731 and 0.886,respectively.Conclusion Serum CTRP9 level in T2DM patients decreases,and serum TNFR1 and FGF23 levels increase.The changes in serum CTRP9,TNFR1 and FGF23 levels are closely related t

关 键 词：2型糖尿病 C1q/肿瘤坏死因子相关蛋白9 肿瘤坏死因子受体1 成纤维细胞生长因子23 下肢动脉血管病变 

分 类 号：R587.1[医药卫生—内分泌]