羟考酮不同给药方法对TURP术后患者致痛物质水平及膀胱痉挛痛的影响  

Effects of Different Administration Methods of Oxycodone on the Level of Pain-Causing Substances and Bladder Spasm Pain in Patients After TURP

作　　者：周雪辉 邵国利[1] 彭丽艳 熊果 ZHOU Xuehui;SHAO Guoli;PENG Liyan(Zhujiang Hospital,Southern Medical University,Guangdong Guangzhou 510000,China)

机构地区：[1]南方医科大学珠江医院,广东广州510000

出　　处：《河北医学》2022年第1期164-168,共5页Hebei Medicine

基　　金：广东省省级科技计划项目,(编号:2020B021800068)。

摘　　要：目的:探究羟考酮不同给药方法对经尿道前列腺切除术(Transurethral resection of prostate,TURP)术后患者致痛物质水平及膀胱痉挛痛的影响。方法:回顾性分析本院2020年3月至2021年3月收治的116行例TURP术患者的临床资料,依据其不同的给药方式分为A、B、C组,A组45例患者采取患者自控静脉镇痛(patient controlled intravenous analgesia,PCIA)持续泵注,B组37例患者采取PCIA单次给药,C组34例患者不采取PCIA镇痛。对比不同组别患者术后致痛物质[血浆P物质、5-羟色胺(5-HT)]水平、48h膀胱痉挛痛次数、视觉模拟评分法(visual analogue scale,VAS)、不良反应发生情况。结果:A、B组患者VAS评分、48h膀胱痉挛次数与总持续时间均明显低于C组,三组患者VAS评分、48h膀胱痉挛次数与总持续时间的组间差异存在统计学意义,P<0.05;A、B组患者P物质、5-HT水平显著低于C组,三组患者P物质、5-HT水平的组间差异存在统计学意义,P<0.05;A(35.56%)、B(32.43%)、C组(20.59%)患者不良反应总发生率差异无统计学意义,P>0.05。结论:羟考酮PCIA持续泵注与单次给药均能够达到TURP术后镇痛及缓解膀胱痉挛痛的作用,且无严重的不良反应,值得临床参考借鉴。Objective:To explore the effects of different administration methods of oxycodone on the level of pain-causing substances and bladder spasm pain in patients after transurethral resection of prostate(TURP).Methods:Researchers retrospectively analyzed the clinical data of 116 TURP patients admitted to our hospital from March 2020 to March 2021,and divided them into groups A,B,and C according to their different administration methods.45 patients in group A adopting patient self-control intravenous analgesia(patient controlled intravenous analgesia,PCIA)were continuously pumped.37 patients in group B received a single PCIA administration,and 34 patients in group C did not take PCIA analgesia.The levels of postoperative pain-causing substances(plasma substance P,5-hydroxytryptamine(5-HT)),the number of bladder cramps at 48 hours,the visual analogue scale(VAS),and the occurrence of adverse reactions were compared among different groups of patients.Results:VAS scores,48h bladder spasms and total duration of patients in groups A and B were significantly lower than those of group C.There were statistically significant differences in VAS scores,48h bladder spasms and total duration between the three groups,P<0.05;The levels of substance P and 5-HT in groups A and B were significantly lower than those in group C.The differences in the levels of substance P and 5-HT in the three groups were statistically significant,P<0.05;Group A(35.56%),B(32.43%)and C(20.59%)had no statistically significant difference in the total incidence of adverse reactions between patients,P>0.05.Conclusion:Both continuous pump injection and single administration of oxycodone PCIA can achieve analgesia and relieve bladder spasm after TURP,and there is no serious adverse reaction,which is worthy of clinical reference.

关 键 词：羟考酮 经尿道前列腺切除术 致痛物质 膀胱痉挛痛 患者自控静脉镇痛 

分 类 号：R699.8[医药卫生—泌尿科学]