INHB、MKRN3、FGFR2在女童中枢性性早熟中的预测价值分析  

Analysis on the predictive value of INHB,MKRN3 and FGFR2 in central precocious puberty of girls

作　　者：吴雪敏 林海丽[2] 林晓 陈瑾[3] WU Xuemin;LIN Haili;LIN Xiao;CHEN Jin(Department of Pediatrics,Taizhou First People′s Hospital,Taizhou 318020,China;Department of Gastroenterology,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou 317000,China;Department of Pediatrics,Taizhou Municipal Hospital,Taizhou 318000,China)

机构地区：[1]台州市第一人民医院儿科,浙江台州318020 [2]浙江省台州医院消化内科,浙江台州317000 [3]台州市立医院儿科,浙江台州318000

出　　处：《中国现代医生》2021年第33期23-26,F0003,共5页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2020KY369)。

摘　　要：目的分析抑制素B(INHB)、Makorin环指蛋白3(MKRN3)、成纤维生长因子受体2(FGFR2)对女童中枢性性早熟的预测价值。方法选取2018年1月至2021年1月期间于我院就诊中枢性性早熟女童100例作为中枢性性早熟组、健康体检的健康女童80名作为健康组。测定血清INHB水平、MKRN3、FGFR2相对表达量,比较三者在健康组、中枢性性早熟组中的表达及与疾病类型的关系,分析三者对此病的预测价值。结果与健康组比较,中枢性性早熟组INHB水平升高,MKRN3、FGFR2相对表达量降低,差异有统计学意义(P<0.001)。进展型中枢性性早熟INHB水平高于缓慢进展型,MKRN3、FGFR2相对表达量低于缓慢进展型,差异有统计学意义(P<0.001)。Pearson相关性分析显示,INHB与MKRN3呈负相关(r=-0.420,P<0.001);INHB与FGFR2呈负相关(r=-0.218,P=0.029);MKRN3与FGFR2呈正相关(r=0.586,P<0.001)。与INHB、MKRN3、FGFR2单项预测比较,三项联合对女童中枢性性早熟的预测价值较高,差异有统计学意义(P<0.05)。结论中枢性性早熟女童血中INHB升高,MKRN3、FGFR2降低,且与疾病类型相关,三者联合对此病的预测价值较高。Objective To analyze the predictive value of inhibin B(INHB),makorin ring finger protein 3(MKRN3),and fibroblast growth factor receptor 2(FGFR2)on central precocious puberty(CPP)of girls.Methods A total of 100 girls with CPP attending our hospital from January 2018 to January 2021 were selected as the CPP group and 80 healthy girls with health checkups as the healthy group.The relative expressions of serum INHB,MKRN3,and FGFR2 were measured,and the expressions of the three were compared between the healthy group and the CPP group.The correlation between the expressions of the three and the type of disease was analyzed,and the predictive value of the three for this disease was analyzed.Results Compared with the healthy group,the INHB level was increased and the relative expressions of MKRN3 and FGFR2 were decreased in the CPP group,with statistically significant differences(P<0.001).The INHB level in progressive CPP was higher than that in slowly progressive CPP,and the relative expressions of MKRN3 and FGFR2 in progressive CPP were lower than those in slowly progressive CPP,with statistically significant differences(P<0.001).Pearson correlation analysis showed that there was a negative correlation between INHB and MKRN3(r=-0.420,P<0.001),and between INHB and FGFR2(r=-0.218,P=0.029),and there was a positive correlation between MKRN3 and FGFR2(r=0.586,P<0.001).Compared with INHB,MKRN3,and FGFR2 alone,the combination of the three had a higher predictive value for CPP of girls,with statistically significant difference(P<0.05).Conclusion The increase of INHB level and the decrease in relative expressions of MKRN3 and FGFR2 in the blood of girls with CPP are correlated with the type of disease,and the combination of the three can achieve a higher predictive value for this disease.

关 键 词：抑制素B Makorin环指蛋白3 成纤维生长因子受体2 女童中枢性性早熟 

分 类 号：R729[医药卫生—儿科]