中药超声雾化治疗睑板腺功能障碍合并蠕形螨感染的临床疗效观察  

Clinical effect of Chinese medicine aerosol fumigation on demodex infection related meibomian gland dysfunction

作　　者：侯小玉 秦亚丽 邓婷婷[3] 金明[3] HOU Xiao-yu;QIN Ya-li;DENG Ting-ting;JIN Ming(Beijing University of Chinese Medicine,Beijing 100029,China;Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510060,China;China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029 [2]中山大学中山眼科中心,广州510060 [3]中日友好医院,北京100029

出　　处：《海南医学院学报》2022年第1期36-40,共5页Journal of Hainan Medical University

基　　金：国家自然科学基金项目(81574029);金明全国名老中医药专家传承工作室;中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者。

摘　　要：目的:观察中药超声雾化治疗睑板腺功能障碍合并蠕形螨感染的临床疗效。方法:收集2020年4月~2021年1月就诊于中日友好医院眼科的睑板腺功能障碍合并蠕形螨感染患者60例(120眼),随机分为2组:试验组30例(60眼)给予中药超声雾化治疗联合睑板腺按摩,对照组30例(60眼)给予睑板腺按摩。在基线、治疗2周后分别记录患者眼部蠕形螨数量、症状评分、泪膜破裂时间(tear break-up time,TBUT)、泪液分泌试验(SchirmerⅠtest,SIT)、睑板腺分泌功能评分、睑板腺分泌物性状评分等指标,并对治疗前后各指标进行分析,比较2组治疗前后的差异性。结果:2组睑板腺功能障碍合并蠕形螨感染患者治疗前眼部蠕形螨数量、症状评分、TBUT、SIT、睑板腺分泌功能评分、睑板腺分泌物性状评分差异均无统计学意义(P>0.05),具有可比性。治疗后,试验组症状评分、睑板腺分泌功能评分、睑板腺分泌物性状评分、眼部蠕形螨数量均较治疗前明显减少,差异均有统计学意义(P<0.01)。试验组治疗后的症状评分、睑板腺分泌功能评分均比对照组低,且眼部蠕形螨数量比对照组少,差异均有统计学意义(P<0.01)。结论:中药超声雾化可缓解睑板腺功能障碍合并蠕形螨感染患者的眼部不适症状,一定程度上减少眼部蠕形螨数量。Objective:To explore the clinical effect of Chinese medicine aerosol fumigation on demodex infection related meibomian gland dysfunction.Methods:A total of 60 patients(120 eyes)were selected and randomly divided into 2 groups:the treatment group(30 cases,60 eyes)was treated with Chinese medicine aerosol fumigation and meibomian gland massage,while the control group(30 cases,60 eyes)was treated with meibomian gland massage.Demodex count,symptom scores,tear breakup time(TBUT),SchirmerⅠtest(SIT),meibomian gland secretion function scores and eyelid fat traits scores were evaluated to compare the difference between the two groups before and after treatment.Results:There was no significant difference in demodex count,symptom scores,TBUT,SIT,meibomian gland secretion function scores and eyelid fat traits scores between the two groups before treatment(P>0.05).After treatment,symptom scores,meibomian gland secretion function scores and eyelid fat traits scores and demodex count of the treatment group were significantly reduced(P<0.01).Moreover,symptom scores,meibomian gland secretion function scores and demodex count of the treatment group were significantly decreased compared with the control group after treatment(P<0.01).Conclusion:Chinese medicine aerosol fumigation can relieve symptoms of of demodex infection related meibomian gland dysfunction and reduce the number of ocular demodex.

关 键 词：蠕形螨 睑板腺功能障碍 中药 超声雾化 

分 类 号：R276.7[医药卫生—中医五官科学]