HMGB1及HMGB2与冠状动脉钙化相关性的分析  

The relationship between HMGB1,HMGB2 and coronary artery calcification

作　　者：刘林鑫 孟华[2] 杨冠旭 李蒙[2] 刘军[2] 陈东昌[2] 李文博 李震南 滑世轩[3] 安松涛[2] 王忠民[2] 陈岩[2] LIU Linxin;MENG Hua;YANG Guanxu;LI Meng;LIU Jun;CHEN Dongchang;LI Wenbo;LI Zhennan;HUA Shixuan;AN Songtao;WANG Zhongmin;CHEN Yan(Department of Cardiology,He'nan Provincial People's Hospital,People's Hospital of He'nan University,Zhengzhou,450003,China;Department of Cardiology,Central China Fuwai Hospital,Henan Provincial People's Hospital;Department of Clinical Laboratory,Central China Fuwai Hospital,Henan Provincial People's Hospital)

机构地区：[1]河南大学人民医院河南省人民医院心内科,郑州450003 [2]河南省人民医院心脏中心华中阜外医院心内科 [3]河南省人民医院心脏中心华中阜外医院检验科

出　　处：《临床心血管病杂志》2021年第12期1085-1089,共5页Journal of Clinical Cardiology

基　　金：河南省医学科技攻关省部共建项目(No:SB201901095)。

摘　　要：目的:探讨血清高迁移率族蛋白1(HMGB1)、血清高迁移率族蛋白2(HMGB2)水平与冠状动脉钙化(CAC)的关系。方法:入选2020年1月—2021年1月于华中阜外医院住院的156例冠心病患者作为试验对象,记录所有患者病史资料、HMGB1以及HMGB2等指标,并进行CAC的分析。将冠心病患者分为非CAC组(62例)与CAC组(94例),比较两组患者临床指标的差异。采用ROC曲线分析HMGB1与HMGB2对CAC的诊断价值,采用logistic回归分析探讨CAC的危险因素。结果:与非CAC组比较,CAC组患者年龄、冠心病病程、BMI、尿酸(UA)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)、高血压病、糖尿病、HMGB1和HMGB2水平均显著升高(均P<0.05),左室射血分数(LVEF)与总胆红素(TBil)水平显著降低(均P<0.05)。ROC曲线显示,HMGB1水平诊断CAC的最佳截点值为6.1773 ng/mL,曲线下面积为0.734(95%CI:0.655~0.813),敏感性为86.2%,特异性为50.0%;HMGB2水平诊断CAC的最佳截点值为5.0396 ng/mL,曲线下面积为0.814(95%CI:0.748~0.881),敏感性为70.2%,特异性为87.1%。多因素logistic回归分析结果显示,TBil是CAC的保护因素,年龄、UA、TG、HbA1c、高血压病、HMGB1、HMGB2是CAC的危险因素。结论:高HMGB1、HMGB2是发生CAC的独立危险因素。Objective:To investigate the relationship between high mobility group box 1(HMGB1),high mobility group box 2(HMGB2),and coronary artery calcification(CAC).Methods:A total of 156 patients with coronary heart disease admitted to Huazhong Fuwai Hospital from January 2020 to January 2021 were enrolled in the study.All patients’medical history,HMGB1,and HMGB2 were recorded,CAC was analyzed.Patients with coronary heart disease were divided into the non-CAC Group(n=62)and CAC group(n=94).The differences in clinical indexes between the two groups were compared.ROC curve was used to analyze the diagnostic value of HMGB1 and HMGB2 in CAC,and logistic regression analysis was used to explore the risk factors of CAC.Results:Compared with the non-CAC group,age,course of coronary heart disease,BMI,uric acid(UA),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),glycosylated hemoglobin(HbA1 c),hypertension,diabetes,HMGB1,and HMGB2 levels in CAC group were significantly increased(all P<0.05),left ventricular ejection fraction(LVEF)and total bilirubin(TBil)level were significantly decreased(all P<0.05).The ROC analysis showed that the best cut-off point of HMGB1 level in diagnosing CAC was 6.1773 ng/mL,the area under the curve was 0.734(95%CI:0.655 to 0.813),the sensitivity was 86.2%,and the specificity was 50.0%;The best cut-off value of HMGB2 level in diagnosing CAC was 5.0396 ng/mL,the area under the curve was 0.814(95%CI:0.748 to 0.881),the sensitivity was 70.2%,and the specificity was 87.1%.Multivariate logistic regression analysis showed that TBil was the protective factor of CAC,and age,UA,TG,HbA1 c,hypertension,HMGB1,and HMGB2 were the risk factors of CAC.Conclusion:High HMGB1 and HMGB2 are independent risk factors for CAC.

关 键 词：血清高迁移率族蛋白1 血清高迁移率族蛋白2 钙化 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]