二硫化钼薄膜制备及其DNA纳米孔测序技术的研究进展  

The Preparation of MoS;Thin Films and DNA Nanopore Sequencing Technology Progress

作　　者：张青云 巩将利 李梓伸 李静 赵彩云 ZHANG Qingyun;GONG Jiangli;LI Zishen;LI Jing;ZHAO Caiyun(Longnan Public Security Bureau,Gansu Longnan 746000;Guang'an Public Security Bureau,Sichuan Guang'an 638000)

机构地区：[1]甘肃省陇南市公安局,甘肃陇南746000 [2]四川省广安市公安局,四川广安638000

出　　处：《生物化工》2021年第6期146-150,共5页Biological Chemical Engineering

摘　　要：二维原子二硫化钼(MoS_(2))薄层材料的纳米孔孔内集成横向纳米电极,可实现二维双通道,在检测DNA分子链易位信号变化的过程中,其因具有样品无需标记、快速读取数据、低成本与高精度等特点而备受关注。本文总结二硫化钼合成及转移方法、纳米孔的制造技术与工作原理等方面的研究进展,分析纳米孔制备方法、表征技术及其优缺点,可为新型纳米孔材料应用到DNA测序技术提供理论支持。Since the horizontal nano-electrode integrated in the nano-hole of the two-dimensional atomic MoS_(2)thin layer material can realize the two-dimensional double-channel,in the process of detecting the change of DNA molecular chain translocation signal,it can realize the sample without labeling,fast data reading,low cost and high precision,which has attracted much attention.In this paper,the research progress in the synthesis and transfer methods of molybdenum disulfide,the manufacturing technology and working principle of nanopores are summarized,and the preparation methods,characterization techniques and advantages and disadvantages of nanopores are analyzed,which can provide theoretical and experimental options for the application of new nanopore materials to DNA sequencing technology.

关 键 词：二硫化钼 纳米孔 制造技术 DNA测序 

分 类 号：TB383[一般工业技术—材料科学与工程]