中国六城市餐饮场所工作人员唾液可替宁和三羟基可替宁浓度水平比较  

Analysis of saliva cotinine and 3′-hydroxynicotinine concentration levels among restaurant workers in six cities of China

作　　者：齐兆斌 肖琳[1] 段佳丽[2] 熊静帆[3] 乐坤蕾 宋钰 王红艳 代佳男 Qi Zhaobin;Xiao Lin;Duan Jiali;Xiong Jingfan;Le Kunlei;Song Yu;Wang Hongyan;Dai Jianan(Tobacco Control Office,Chinese Center for Disease Control and Prevention,Beijing 100050,China;Beijing Center for Disease Control and Prevention Health Promotion Office,Beijing 100013,China;Shenzhen Chronic Disease Prevention Center,Shenzhen 518020,China;Shanghai Health Promotion Center Tobacco Control and Behavior Intervention Department,Shanghai 200040,China;Shenyang Health Service Center,Shenyang 110031,China;Hunan Health Committee Health Education Publicity Center,Changsha 410005,China;Chongqing Health Education Institute and Tobacco Control Office,Chongqing 401120,China)

机构地区：[1]中国疾病预防控制中心控烟办公室,北京100050 [2]北京市疾病预防控制中心健康促进办公室,100013 [3]深圳市慢性病防治中心,518020 [4]上海市健康促进中心控烟与行为干预部,200040 [5]沈阳市卫生健康教育中心,110031 [6]湖南省卫生健康委健康教育宣传中心,长沙410005 [7]重庆市健康教育所控烟办公室,401120

出　　处：《中华预防医学杂志》2021年第12期1482-1485,共4页Chinese Journal of Preventive Medicine

基　　金：世界卫生组织(2020/1042832⁃0)。

摘　　要：2020年11—12月,纳入北京、上海、深圳(已出台全面无烟立法)和长沙、重庆、沈阳(未出台全面无烟立法)6城市的678名餐饮场所工作人员为研究对象,年龄为(35.61±12.91)岁;已出台全面无烟立法城市者占49.71%(337名);男性占19.47%(132名);大、中和小型餐饮场所的研究对象分别占13.57%(92名)、37.32%(253名)和49.11%(333名)。经检测研究对象的唾液样本中的可替宁和三羟基可替宁,已出台全面无烟立法城市对象唾液中可替宁[34.12%(115/337)]、三羟基可替宁检出率[16.32%(55/337)]均低于未出台全面无烟立法城市对象的可替宁[68.04%(232/341)]、三羟基可替宁检出率[41.94%(143/341)](P值均<0.001);已出台全面无烟立法城市对象唾液可替宁和三羟基可替宁浓度(0.250 ng/ml、0.250 ng/ml)均低于未出台全面无烟立法城市对象唾液可替宁和三羟基可替宁浓度(0.742 ng/ml、0.250 ng/ml)(P值均<0.001);不同规模餐饮场所对象可替宁和三羟基可替宁浓度差异没有统计学意义(P值均>0.05)。This study was conducted between November to December 2020,consisting of six representative cities,Beijing,Shanghai,Shenzhen(with comprehensive smoke-free legislation),and Changsha,Chongqing,Shenyang(without comprehensive smoke-free legislation),678 subjects were enrolled eventually,the mean age of the 678 subjects was(35.61±12.91)years old.Subjects from cities with comprehensive smoke-free legislation accounted for 49.71%of the total;male subjects accounted for 19.47%;meanwhile subjects from large,medium,and small restaurants accounted for 13.57%(92),37.32%(253)and 49.11%(333)respectively.The analysis results indicate that the positive rate of restaurants staff of cotinine and 3′-hydroxynicotinine was lower in cities with comprehensive smoke-free legislation(34.12%vs 68.04%,χ^(2)=78.01,P<0.001;16.32%vs 41.94%,χ^(2)=53.79,P<0.001),with staff from cities with comprehensive smoke-free legislation have lower concentrations of cotinine and 3′-hydroxynicotinine than their counterparts from cities without comprehensive smoke-free legislation(0.250 ng/ml vs 0.742 ng/ml,P<0.001;0.250 ng/ml vs 0.250 ng/ml,P<0.001).No statistically significant difference in the concentration of cotinine and 3′-hydroxynicotinine in saliva between staff from restaurants of different sizes was detected(P>0.05).

关 键 词：烟草烟污染 可替宁 横断面研究 三羟基可替宁 

分 类 号：R193.3[医药卫生—卫生事业管理]