基于Nrf2信号通路的中药促进糖尿病创面愈合研究进展  

Effect of Chinese Medicine on Diabetic Wound Based on Nrf2 Signaling Pathway:A Review

作　　者：周鑫[1,2] 刘鹏 郭燕玲[1,2] 许彪 牛文晶 王军 ZHOU Xin;LIU Peng;GUO Yan-ling;XU Biao;NIU Wen-jing;WANG Jun(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine(TCM),National Clinical Research Center for Chinese Medicine Acupuncture Moxibustion,Tianjin 300193,China;Graduate School of Tianjin University of TCM,Tianjin 301617,China)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300193 [2]天津中医药大学研究生院,天津301617

出　　处：《中国实验方剂学杂志》2022年第3期241-249,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81973854,81473685);天津市自然科学基金项目(18JCYBJC93600);天津市卫生健康委员会中医药重点领域科研项目(2019008)。

摘　　要：糖尿病创面愈合障碍是糖尿病常见的慢性并发症之一,严重影响患者生活质量,甚至致残、致死,给社会带来了沉重的负担。中药是我国独特且珍贵的资源,具有较好的疗效和安全性。氧化应激在糖尿病创面的发生发展中有重要作用,体内抗氧化防御机制紊乱是导致糖尿病创面迁延不愈的因素之一。核因子E2相关因子2(Nrf2)是机体内维持细胞内氧化还原稳态的重要转录因子,可调节氧化/异源性应激并减少炎症反应。Nrf2对正常伤口的愈合并不是必须的,而对糖尿病伤口的愈合却至关重要。目前发现许多中药及其有效成分能有效促进糖尿病创面愈合,其机制与激活Nrf2信号通路有关。中药靶向激活Nrf2可减轻糖尿病创面的氧化应激反应、炎症反应和细胞凋亡,从而延缓症状的进一步加重,是促进糖尿病创面愈合药物的潜在靶点。该文总结了Nrf2信号通路与糖尿病创面的关系,并分析中药及其有效成分通过调节Nrf2通路促进糖尿病创面愈合的作用方式及可能机制,以期为创制基于该通路的糖尿病创面治疗药物提供参考。Diabetic wound healing disorder,one of the common chronic complications of diabetes,seriously influences the quality of life of patients and even causes disability and death,bringing a heavy burden to the society.Chinese medicine,a unique and precious resource in China,is safe with definite effect.Oxidative stress plays an important role in the occurrence and development of diabetic wound and the disturbance of antioxidant defense mechanism is among the causes of the lingering diabetic wound.As a vital transcription factor for intracellular redox homeostasis,nuclear factor erythroid 2-related factor 2(Nrf2)regulates oxidative/heterogenous stress and reduces inflammatory responses.Although it is unnecessary for common wound healing,it is of great importance for diabetic wound healing.Many Chinese medicinals and the active ingredients have been found to enhance diabetic wound healing by mechanisms related to activation of the Nrf2 signaling pathway.Targeted activation of Nrf2 by Chinese medicine can alleviate oxidative stress,inflammatory response,and apoptosis in diabetic wound,thereby delaying further exacerbation of symptoms.Therefore,Nrf2 is regarded as a potential target for drugs to boost diabetic wound healing.This study summarizes the relationship between the Nrf2 signaling pathway and diabetic wound and analyzes the mode of action and possible mechanisms of Chinese medicine and its active ingredients in promoting diabetic wound healing through modulating the Nrf2 pathway,which is expected to serve as a reference for developing drugs for diabetic wound based on this pathway.

关 键 词：糖尿病创面 核因子E_(2)相关因子2(Nrf2) 氧化应激 中药 有效成分 

分 类 号：R2-0[医药卫生—中医学] R22