杭州市西湖区2019-2020年入托入园儿童乙型肝炎疫苗接种率和乙型肝炎血清流行率调查  

Hepatitis B vaccine coverage and hepatitis B seroprevalence among children entering kindergarten in Xihu district, Hangzhou city in 2019-2020

作　　者：徐娜妮[1] 周筱丛 胡小炜[1] 郑琳[1] 范从娟 温晓群 Xu Nani;Zhou Xiaocong;Hu Xiaowei;Zheng Lin;Fan Congjuan;Wen Xiaoqun(Xihu District Center for Disease Control and Prevention,Hangzhou 310030,Zhejiang,China;Zhejiang Traditional Chinese Medicine University,Hangzhou 310053,Zhejiang,China;Wenxin Street Community Health Service Center of Xihu District,Hangzhou 310012,Zhejiang,China)

机构地区：[1]杭州市西湖区疾病预防控制中心,浙江杭州310030 [2]浙江中医药大学,浙江杭州310053 [3]杭州市西湖区文新街道社区卫生服务中心,浙江杭州310012

出　　处：《中国疫苗和免疫》2021年第6期627-630,共4页Chinese Journal of Vaccines and Immunization

基　　金：中国肝炎防治基金会中国乙肝防控科研基金资助项目(YGFK20190070)。

摘　　要：目的了解杭州市西湖区入托入园儿童乙型肝炎(乙肝)疫苗(Hepatitis B vaccine, HepB)接种率和乙肝血清流行率。方法采用简单随机抽样方法在西湖区选取2019-2020年入托入园儿童,收集HepB接种信息,采集血清标本,应用化学发光微粒子免疫试验检测乙肝表面抗原(Hepatitis B surface antigen, HBsAg)和乙肝表面抗体(Hepatitis B surface antibody, HBsAb),分析HepB接种率和乙肝血清流行率。结果共纳入3 817名调查对象,HepB全程接种率、出生24h内首剂接种率分别为99.69%(95%CI:99.51%-99.86%)、95.31%(95%CI:94.64%-95.98%);HBsAg阳性率为0.39%(95%CI:0.19%-0.58%);HBsAb阳性率和几何平均浓度分别为92.17%(95%CI:91.31%-93.02%)、97.90(95%CI:92.41-103.73)mIU/mL。结论西湖区2019-2020年入托入园儿童HepB接种率高而HBsAg携带率低,且仍具有良好的乙肝免疫力。Objective To determine hepatitis B vaccine(HepB) coverage and hepatitis B seroprevalence among children entering kindergarten in Xihu district, Hangzhou city.Methods We used a simple random sampling method to recruit children entering kindergarten during the 2019-2020 school year. We collected information on HepB vaccination to determine HepB vaccination histories. We tested serum samples for hepatitis B surface antigen(HBsAg) and hepatitis B surface antibody(HBsAb) using chemiluminescence microparticle immunoassay to determine sero-positivity.Results A total of 3 817 children were recruited into the study. Among all subjects, coverage levels of full-series HepB and receipt of the first dose of HepB within 24 hours of birth were 99.69%(95%CI: 99.51%-99.86%) and 95.31%(95%CI: 94.64%-95.98%), respectively. The HBsAg seroprevalence was 0.39%(95%CI: 0.19%-0.58%), and the positivity rate and geometric mean concentration of HBsAb were 92.17%(95%CI: 91.31%-93.02%) and 97.90(95%CI: 92.41-103.73) mIU/mL, respectively.Conclusions HepB coverage was high while HBsAg carriage was low among children entering kindergarten in Xihu district. Children entering kindergarten have good immunity against hepatitis B virus.

关 键 词：乙型肝炎疫苗 乙型肝炎表面抗原 乙型肝炎表面抗体 接种率 血清流行率 托幼机构 儿童 

分 类 号：R186[医药卫生—流行病学]