Genome-wide association study identifies quantitative trait loci affecting cattle temperament  

作　　者：Jia-Fei Shen Qiu-Ming Chen Feng-Wei Zhang Quratulain Hanif Bi-Zhi Huang Ning-Bo Chen Kai-Xing Qu Jing-Xi Zhan Hong Chen Yu Jiang Chu-Zhao Lei 

机构地区：[1]Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China [2]College of Animal Science,Xinjiang Agricultural University,Urumqi,Xinjiang 830052,China [3]National Institute for Biotechnology and Genetic Engineering,Pakistan Institute of Engineering and Applied Sciences,Faisalabad 577,Pakistan [4]Yunnan Academy of Grassland and Animal Science,Kunming,Yunnan 650212,China [5]Academy of Science and Technology,Chuxiong Normal University,Chuxiong,Yunnan 675000,China

出　　处：《Zoological Research》2022年第1期14-25,共12页动物学研究（英文）

基　　金：supported by the National Natural Science Foundation of China(31872317);China Agriculture Research System of MOF and MARA(CARS-37)。

摘　　要：Cattle temperament is an interesting trait due to its correlation with production efficiency,labor safety,and animal welfare.To date,however,its genetic basis is not clearly understood.Here,we performed a genome-wide association study for a series of temperament traits in cattle,assessed with via open field and novel object tests,using autosomal single nucleotide polymorphisms(SNPs)derived from the whole-genome sequence.We identified 37 and 29 genome-wide significant loci in the open field and novel object tests,respectively.Gene set analysis revealed the most significant pathway was the neuroactive ligand-receptor interaction pathway,which may be essential for emotional control in cattle.Analysis of the expression levels of 18 tissue-specific genes based on transcriptomic data showed enrichment in the brain,with some candidate genes involved in psychiatric and neurodegenerative diseases in humans.Based on principal component analysis,the first principal component explained the largest variance in the open field and novel object test data,and the most significant loci were assigned to SORCS3 and SESTD1,respectively.Our findings should help facilitate cattle breeding for sound temperament by pyramiding favorable alleles to further improve cattle production.

关 键 词：Cattle temperament Open field test Novel object test SORCS3 SESTD1 

分 类 号：S823.2[农业科学—畜牧学]